Norepinephrine-induced depolarization of skeletal muscle cells

Nancy Teskey, Barbara A Horwitz, John Horowitz

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

I.v. administration of norepinephrine to anesthetized hamsters was followed by a significant depolarization of the cell membranes of skeletal muscle (gracilis anticus and sartorius). The occurrence of this depolarization is consistent with the suggestion that changes in ionic distribution across the cell membrane are associated with activation of non-shivering thermogenesis in muscle cells as has been proposed for brown adipocytes.

Original languageEnglish (US)
Pages (from-to)352-355
Number of pages4
JournalEuropean Journal of Pharmacology
Volume30
Issue number2
DOIs
StatePublished - 1975

Keywords

  • Catecholamine
  • Heat production
  • Membrane depolarization
  • Non-shivering thermogenesis
  • Norepinephrine
  • Skeletal muscle

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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