Norepinephrine and amino acids in prepyriform cortex of rats fed imbalanced amino acid diets

Dorothy W. Gietzen, Philip M.B. Leung, Quinton Rogers

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Monoamines and amino acids were measured in anterior prepyriform cortex (PPC) and anterior cingulate cortex (CC) of male Sprague-Dawley rats after they were offered basal, imbalanced (IMB) or corrected amino acid diets, limited in threonine (THR) or isoleucine (ILE). In the THR study, brains were taken after 2.5 hr of feeding, when intake of THR-IMB was just depressed. In the ILE study the brains were taken after 3.5 hr on ILE-IMB, a less severely imbalanced ration, before the onset of food intake depression. The PPC has been shown to be involved in the acute response of animals to imbalanced amino acid diets. In the PPC from the IMB diet groups, NE was reduced by 30%, but the other monoamines were unchanged. In CC, an area involved in the adaptive, but not the acute feeding response to imbalanced diets, the monoamines were unchanged in the IMB diet groups. In both studies, in both tissues, the limiting amino acids were decreased in the IMB groups, although the decrease of ILE in the CC failed to reach significance. The remaining indispensable amino acids, added to create the imbalance, were slightly reduced in the THR-IMB group, but not in the ILE-IMB group in both tissues. Thus, the amino acid patterns were altered in the PPC and CC, as they are in whole brains from animals fed imbalanced amino acid diets. These results also suggest that the concentration of NE in the PPC may be associated with the initial food intake response of animals to imbalanced amino acid diets.

Original languageEnglish (US)
Pages (from-to)1071-1080
Number of pages10
JournalPhysiology and Behavior
Volume36
Issue number6
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Norepinephrine
Isoleucine
Diet
Amino Acids
Gyrus Cinguli
Threonine
Brain
Eating
Piriform Cortex
Sprague Dawley Rats

Keywords

  • Amino acid imbalance
  • Amino acids
  • Cingulate cortex
  • Monoamines
  • Norepinephrine
  • Prepyriform cortex
  • Rat

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Norepinephrine and amino acids in prepyriform cortex of rats fed imbalanced amino acid diets. / Gietzen, Dorothy W.; Leung, Philip M.B.; Rogers, Quinton.

In: Physiology and Behavior, Vol. 36, No. 6, 01.01.1986, p. 1071-1080.

Research output: Contribution to journalArticle

Gietzen, Dorothy W. ; Leung, Philip M.B. ; Rogers, Quinton. / Norepinephrine and amino acids in prepyriform cortex of rats fed imbalanced amino acid diets. In: Physiology and Behavior. 1986 ; Vol. 36, No. 6. pp. 1071-1080.
@article{22df1dd98b1b4af4b8c4bbe323167107,
title = "Norepinephrine and amino acids in prepyriform cortex of rats fed imbalanced amino acid diets",
abstract = "Monoamines and amino acids were measured in anterior prepyriform cortex (PPC) and anterior cingulate cortex (CC) of male Sprague-Dawley rats after they were offered basal, imbalanced (IMB) or corrected amino acid diets, limited in threonine (THR) or isoleucine (ILE). In the THR study, brains were taken after 2.5 hr of feeding, when intake of THR-IMB was just depressed. In the ILE study the brains were taken after 3.5 hr on ILE-IMB, a less severely imbalanced ration, before the onset of food intake depression. The PPC has been shown to be involved in the acute response of animals to imbalanced amino acid diets. In the PPC from the IMB diet groups, NE was reduced by 30{\%}, but the other monoamines were unchanged. In CC, an area involved in the adaptive, but not the acute feeding response to imbalanced diets, the monoamines were unchanged in the IMB diet groups. In both studies, in both tissues, the limiting amino acids were decreased in the IMB groups, although the decrease of ILE in the CC failed to reach significance. The remaining indispensable amino acids, added to create the imbalance, were slightly reduced in the THR-IMB group, but not in the ILE-IMB group in both tissues. Thus, the amino acid patterns were altered in the PPC and CC, as they are in whole brains from animals fed imbalanced amino acid diets. These results also suggest that the concentration of NE in the PPC may be associated with the initial food intake response of animals to imbalanced amino acid diets.",
keywords = "Amino acid imbalance, Amino acids, Cingulate cortex, Monoamines, Norepinephrine, Prepyriform cortex, Rat",
author = "Gietzen, {Dorothy W.} and Leung, {Philip M.B.} and Quinton Rogers",
year = "1986",
month = "1",
day = "1",
doi = "10.1016/0031-9384(86)90482-8",
language = "English (US)",
volume = "36",
pages = "1071--1080",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Norepinephrine and amino acids in prepyriform cortex of rats fed imbalanced amino acid diets

AU - Gietzen, Dorothy W.

AU - Leung, Philip M.B.

AU - Rogers, Quinton

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Monoamines and amino acids were measured in anterior prepyriform cortex (PPC) and anterior cingulate cortex (CC) of male Sprague-Dawley rats after they were offered basal, imbalanced (IMB) or corrected amino acid diets, limited in threonine (THR) or isoleucine (ILE). In the THR study, brains were taken after 2.5 hr of feeding, when intake of THR-IMB was just depressed. In the ILE study the brains were taken after 3.5 hr on ILE-IMB, a less severely imbalanced ration, before the onset of food intake depression. The PPC has been shown to be involved in the acute response of animals to imbalanced amino acid diets. In the PPC from the IMB diet groups, NE was reduced by 30%, but the other monoamines were unchanged. In CC, an area involved in the adaptive, but not the acute feeding response to imbalanced diets, the monoamines were unchanged in the IMB diet groups. In both studies, in both tissues, the limiting amino acids were decreased in the IMB groups, although the decrease of ILE in the CC failed to reach significance. The remaining indispensable amino acids, added to create the imbalance, were slightly reduced in the THR-IMB group, but not in the ILE-IMB group in both tissues. Thus, the amino acid patterns were altered in the PPC and CC, as they are in whole brains from animals fed imbalanced amino acid diets. These results also suggest that the concentration of NE in the PPC may be associated with the initial food intake response of animals to imbalanced amino acid diets.

AB - Monoamines and amino acids were measured in anterior prepyriform cortex (PPC) and anterior cingulate cortex (CC) of male Sprague-Dawley rats after they were offered basal, imbalanced (IMB) or corrected amino acid diets, limited in threonine (THR) or isoleucine (ILE). In the THR study, brains were taken after 2.5 hr of feeding, when intake of THR-IMB was just depressed. In the ILE study the brains were taken after 3.5 hr on ILE-IMB, a less severely imbalanced ration, before the onset of food intake depression. The PPC has been shown to be involved in the acute response of animals to imbalanced amino acid diets. In the PPC from the IMB diet groups, NE was reduced by 30%, but the other monoamines were unchanged. In CC, an area involved in the adaptive, but not the acute feeding response to imbalanced diets, the monoamines were unchanged in the IMB diet groups. In both studies, in both tissues, the limiting amino acids were decreased in the IMB groups, although the decrease of ILE in the CC failed to reach significance. The remaining indispensable amino acids, added to create the imbalance, were slightly reduced in the THR-IMB group, but not in the ILE-IMB group in both tissues. Thus, the amino acid patterns were altered in the PPC and CC, as they are in whole brains from animals fed imbalanced amino acid diets. These results also suggest that the concentration of NE in the PPC may be associated with the initial food intake response of animals to imbalanced amino acid diets.

KW - Amino acid imbalance

KW - Amino acids

KW - Cingulate cortex

KW - Monoamines

KW - Norepinephrine

KW - Prepyriform cortex

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0022541588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022541588&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(86)90482-8

DO - 10.1016/0031-9384(86)90482-8

M3 - Article

C2 - 3088622

AN - SCOPUS:0022541588

VL - 36

SP - 1071

EP - 1080

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 6

ER -