In order to evaluate the role of norepinephrine in regulating activity of (Na+, K+)-ATPase in vivo, enzyme activity was measured in rat brain after electrical stimulation of the locus coeruleus and after administration of piperoxane. Both treatments resulted in increased (Na+, K+)-ATPase activity in locus coeruleus projection areas, but not in corpus striatum. The increased activity was limited to the same side as the stimulating electrode. Destruction of noradrenergic fibers from the locus coeruleus with 6-hydroxydopamine prevented the increase in enzyme activity with piperoxane.
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