Noradrenergic stimulation in vivo increases (Na+, K+)-adenosine triphosphatase activity

Alan C. Swann, Jacqueline Crawley, Steven J. Grant, James W. Maas

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


In order to evaluate the role of norepinephrine in regulating activity of (Na+, K+)-ATPase in vivo, enzyme activity was measured in rat brain after electrical stimulation of the locus coeruleus and after administration of piperoxane. Both treatments resulted in increased (Na+, K+)-ATPase activity in locus coeruleus projection areas, but not in corpus striatum. The increased activity was limited to the same side as the stimulating electrode. Destruction of noradrenergic fibers from the locus coeruleus with 6-hydroxydopamine prevented the increase in enzyme activity with piperoxane.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalLife Sciences
Issue number3
StatePublished - Jan 19 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology


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