Noradrenergic stimulation in vivo increases (Na+, K+)-adenosine triphosphatase activity

Alan C. Swann, Jacqueline Crawley, Steven J. Grant, James W. Maas

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In order to evaluate the role of norepinephrine in regulating activity of (Na+, K+)-ATPase in vivo, enzyme activity was measured in rat brain after electrical stimulation of the locus coeruleus and after administration of piperoxane. Both treatments resulted in increased (Na+, K+)-ATPase activity in locus coeruleus projection areas, but not in corpus striatum. The increased activity was limited to the same side as the stimulating electrode. Destruction of noradrenergic fibers from the locus coeruleus with 6-hydroxydopamine prevented the increase in enzyme activity with piperoxane.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalLife Sciences
Volume28
Issue number3
DOIs
StatePublished - Jan 19 1981
Externally publishedYes

Fingerprint

Piperoxan
Locus Coeruleus
Enzyme activity
Adenosine Triphosphatases
Oxidopamine
Corpus Striatum
Rats
Brain
Norepinephrine
Deep Brain Stimulation
Enzymes
Electrodes
Fibers
sodium-translocating ATPase
Therapeutics

ASJC Scopus subject areas

  • Pharmacology

Cite this

Noradrenergic stimulation in vivo increases (Na+, K+)-adenosine triphosphatase activity. / Swann, Alan C.; Crawley, Jacqueline; Grant, Steven J.; Maas, James W.

In: Life Sciences, Vol. 28, No. 3, 19.01.1981, p. 251-256.

Research output: Contribution to journalArticle

Swann, Alan C. ; Crawley, Jacqueline ; Grant, Steven J. ; Maas, James W. / Noradrenergic stimulation in vivo increases (Na+, K+)-adenosine triphosphatase activity. In: Life Sciences. 1981 ; Vol. 28, No. 3. pp. 251-256.
@article{ababbb6a3ba44ef382b5a6d33e8dc6c2,
title = "Noradrenergic stimulation in vivo increases (Na+, K+)-adenosine triphosphatase activity",
abstract = "In order to evaluate the role of norepinephrine in regulating activity of (Na+, K+)-ATPase in vivo, enzyme activity was measured in rat brain after electrical stimulation of the locus coeruleus and after administration of piperoxane. Both treatments resulted in increased (Na+, K+)-ATPase activity in locus coeruleus projection areas, but not in corpus striatum. The increased activity was limited to the same side as the stimulating electrode. Destruction of noradrenergic fibers from the locus coeruleus with 6-hydroxydopamine prevented the increase in enzyme activity with piperoxane.",
author = "Swann, {Alan C.} and Jacqueline Crawley and Grant, {Steven J.} and Maas, {James W.}",
year = "1981",
month = "1",
day = "19",
doi = "10.1016/0024-3205(81)90730-X",
language = "English (US)",
volume = "28",
pages = "251--256",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Noradrenergic stimulation in vivo increases (Na+, K+)-adenosine triphosphatase activity

AU - Swann, Alan C.

AU - Crawley, Jacqueline

AU - Grant, Steven J.

AU - Maas, James W.

PY - 1981/1/19

Y1 - 1981/1/19

N2 - In order to evaluate the role of norepinephrine in regulating activity of (Na+, K+)-ATPase in vivo, enzyme activity was measured in rat brain after electrical stimulation of the locus coeruleus and after administration of piperoxane. Both treatments resulted in increased (Na+, K+)-ATPase activity in locus coeruleus projection areas, but not in corpus striatum. The increased activity was limited to the same side as the stimulating electrode. Destruction of noradrenergic fibers from the locus coeruleus with 6-hydroxydopamine prevented the increase in enzyme activity with piperoxane.

AB - In order to evaluate the role of norepinephrine in regulating activity of (Na+, K+)-ATPase in vivo, enzyme activity was measured in rat brain after electrical stimulation of the locus coeruleus and after administration of piperoxane. Both treatments resulted in increased (Na+, K+)-ATPase activity in locus coeruleus projection areas, but not in corpus striatum. The increased activity was limited to the same side as the stimulating electrode. Destruction of noradrenergic fibers from the locus coeruleus with 6-hydroxydopamine prevented the increase in enzyme activity with piperoxane.

UR - http://www.scopus.com/inward/record.url?scp=0019493956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019493956&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(81)90730-X

DO - 10.1016/0024-3205(81)90730-X

M3 - Article

VL - 28

SP - 251

EP - 256

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 3

ER -