Nonstimulated human uncommitted mesenchymal stem cells express cell markers of mesenchymal and neural lineages

José J. Minguell, Fernando A Fierro, María J. Epuñan, Alejandro A. Erices, Walter D. Sierralta

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Ex vivo cultures of human bone marrow-derived mesenchymal stem cells (MSCs) contain subsets of progenitors exhibiting dissimilar properties. One of these subsets comprises uncommitted progenitors displaying distinctive features, such as morphology, a quiescent condition, growth factor production, and restricted tissue biodistribution after transplantation. In this study, we assessed the competence of these cells to express, in the absence of differentiation stimuli, markers of mesoderm and ectodermic (neural) cell lineages. Fluorescence microscopy analysis showed a unique pattern of expression of osteogenic, chondrogenic, muscle, and neural markers. The depicted "molecular signature" of these early uncommitted progenitors, in the absence of differentiation stimuli, is consistent with their multipotentiality and plasticity as suggested by several in vitro and in vivo studies.

Original languageEnglish (US)
Pages (from-to)408-414
Number of pages7
JournalStem Cells and Development
Volume14
Issue number4
DOIs
StatePublished - Aug 2005
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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