Nonlithographic fabrication of microfluidic devices

Valentine I. Vullev, Jiandi Wan, Volkmar Heinrich, Pavel Landsman, Paul E. Bower, Bing Xia, Brent Millare, Guilford Jones

Research output: Contribution to journalArticle

50 Scopus citations


A facile nonlithographic method for expedient fabrication of microfluidic devices of poly(dimethylsiloxane) is described. Positive-relief masters for the molds are directly printed on smooth substrates. For the formation of connecting channels and chambers inside the polymer components of the microfluidic devices, cavity-forming elements are adhered to the surfaces of the masters. Using this nonlithographic approach, we fabricated microfluidic devices for detection of bacterial spores on the basis of enhancement of the emission of terbium (III) ions.

Original languageEnglish (US)
Pages (from-to)16062-16072
Number of pages11
JournalJournal of the American Chemical Society
Issue number50
StatePublished - Dec 20 2006


ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Vullev, V. I., Wan, J., Heinrich, V., Landsman, P., Bower, P. E., Xia, B., Millare, B., & Jones, G. (2006). Nonlithographic fabrication of microfluidic devices. Journal of the American Chemical Society, 128(50), 16062-16072.