Nonlinear pressure-flow relationships for passive microfluidic valves

Erkin Seker, Daniel C. Leslie, Hossein Haj-Hariri, James P. Landers, Marcel Utz, Matthew R. Begley

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

An analytical solution is presented for the nonlinear pressure-flow relationship of deformable passive valves, which are formed by bonding a deformable film over etched channels separated by a weir. A fluidic pathway connecting the channels is opened when the upstream pressure creates a tunnel along a predefined narrow strip where the film is not bonded to the weir. When the width of the strip is comparable to the inlet channel width, the predicted closed-form pressure-flow rate relationship is in excellent agreement with experiments, which determine pressures by measuring film deflections for prescribed flow rates. The validated closed-form models involve no fitting parameters, and provide the foundation to design passive diodes with specific nonlinear pressure-flow characteristics.

Original languageEnglish (US)
Pages (from-to)2691-2697
Number of pages7
JournalLab on a Chip
Volume9
Issue number18
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

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Microfluidics
Pressure
Flow rate
Fluidics
Tunnels
Diodes
Experiments

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Seker, E., Leslie, D. C., Haj-Hariri, H., Landers, J. P., Utz, M., & Begley, M. R. (2009). Nonlinear pressure-flow relationships for passive microfluidic valves. Lab on a Chip, 9(18), 2691-2697. https://doi.org/10.1039/b903960k

Nonlinear pressure-flow relationships for passive microfluidic valves. / Seker, Erkin; Leslie, Daniel C.; Haj-Hariri, Hossein; Landers, James P.; Utz, Marcel; Begley, Matthew R.

In: Lab on a Chip, Vol. 9, No. 18, 01.01.2009, p. 2691-2697.

Research output: Contribution to journalArticle

Seker, E, Leslie, DC, Haj-Hariri, H, Landers, JP, Utz, M & Begley, MR 2009, 'Nonlinear pressure-flow relationships for passive microfluidic valves', Lab on a Chip, vol. 9, no. 18, pp. 2691-2697. https://doi.org/10.1039/b903960k
Seker E, Leslie DC, Haj-Hariri H, Landers JP, Utz M, Begley MR. Nonlinear pressure-flow relationships for passive microfluidic valves. Lab on a Chip. 2009 Jan 1;9(18):2691-2697. https://doi.org/10.1039/b903960k
Seker, Erkin ; Leslie, Daniel C. ; Haj-Hariri, Hossein ; Landers, James P. ; Utz, Marcel ; Begley, Matthew R. / Nonlinear pressure-flow relationships for passive microfluidic valves. In: Lab on a Chip. 2009 ; Vol. 9, No. 18. pp. 2691-2697.
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