Noninvasive thermometry assisted by a dual-function ultrasound transducer for mild hyperthermia

Chun Yen Lai, Dustin E. Kruse, Charles F. Caskey, Douglas N. Stephens, Patrick L. Sutcliffe, Katherine W. Ferrara

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Mild hyperthermia is increasingly important for the activation of temperature-sensitive drug delivery vehicles. Noninvasive ultrasound thermometry based on a 2-D speckle tracking algorithm was examined in this study. Here, a commercial ultrasound scanner, a customized co-linear array transducer, and a controlling PC system were used to generate mild hyperthermia. Because the co-linear array transducer is capable of both therapy and imaging at widely separated frequencies, RF image frames were acquired during therapeutic insonation and then exported for off-line analysis. For in vivo studies in a mouse model, before temperature estimation, motion correction was applied between a reference RF frame and subsequent RF frames. Both in vitro and in vivo experiments were examined; in the in vitro and in vivo studies, the average temperature error had a standard deviation of 0.7°C and 0.8°C, respectively. The application of motion correction improved the accuracy of temperature estimation, where the error range was -1.9 to 4.5°C without correction compared with -1.1 to 1.0°C following correction. This study demonstrates the feasibility of combining therapy and monitoring using a commercial system. In the future, real-time temperature estimation will be incorporated into this system.

Original languageEnglish (US)
Article number5610553
Pages (from-to)2671-2684
Number of pages14
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Issue number12
StatePublished - Dec 2010

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Acoustics and Ultrasonics
  • Instrumentation


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