Abstract
Mild hyperthermia is increasingly important for the activation of temperature-sensitive drug delivery vehicles. Noninvasive ultrasound thermometry based on a 2-D speckle tracking algorithm was examined in this study. Here, a commercial ultrasound scanner, a customized co-linear array transducer, and a controlling PC system were used to generate mild hyperthermia. Because the co-linear array transducer is capable of both therapy and imaging at widely separated frequencies, RF image frames were acquired during therapeutic insonation and then exported for off-line analysis. For in vivo studies in a mouse model, before temperature estimation, motion correction was applied between a reference RF frame and subsequent RF frames. Both in vitro and in vivo experiments were examined; in the in vitro and in vivo studies, the average temperature error had a standard deviation of 0.7°C and 0.8°C, respectively. The application of motion correction improved the accuracy of temperature estimation, where the error range was -1.9 to 4.5°C without correction compared with -1.1 to 1.0°C following correction. This study demonstrates the feasibility of combining therapy and monitoring using a commercial system. In the future, real-time temperature estimation will be incorporated into this system.
| Original language | English (US) |
|---|---|
| Article number | 5610553 |
| Pages (from-to) | 2671-2684 |
| Number of pages | 14 |
| Journal | IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control |
| Volume | 57 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2010 |
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ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Acoustics and Ultrasonics
- Instrumentation
Cite this
Noninvasive thermometry assisted by a dual-function ultrasound transducer for mild hyperthermia. / Lai, Chun Yen; Kruse, Dustin E.; Caskey, Charles F.; Stephens, Douglas N.; Sutcliffe, Patrick L.; Ferrara, Katherine W.
In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 57, No. 12, 5610553, 12.2010, p. 2671-2684.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Noninvasive thermometry assisted by a dual-function ultrasound transducer for mild hyperthermia
AU - Lai, Chun Yen
AU - Kruse, Dustin E.
AU - Caskey, Charles F.
AU - Stephens, Douglas N.
AU - Sutcliffe, Patrick L.
AU - Ferrara, Katherine W.
PY - 2010/12
Y1 - 2010/12
N2 - Mild hyperthermia is increasingly important for the activation of temperature-sensitive drug delivery vehicles. Noninvasive ultrasound thermometry based on a 2-D speckle tracking algorithm was examined in this study. Here, a commercial ultrasound scanner, a customized co-linear array transducer, and a controlling PC system were used to generate mild hyperthermia. Because the co-linear array transducer is capable of both therapy and imaging at widely separated frequencies, RF image frames were acquired during therapeutic insonation and then exported for off-line analysis. For in vivo studies in a mouse model, before temperature estimation, motion correction was applied between a reference RF frame and subsequent RF frames. Both in vitro and in vivo experiments were examined; in the in vitro and in vivo studies, the average temperature error had a standard deviation of 0.7°C and 0.8°C, respectively. The application of motion correction improved the accuracy of temperature estimation, where the error range was -1.9 to 4.5°C without correction compared with -1.1 to 1.0°C following correction. This study demonstrates the feasibility of combining therapy and monitoring using a commercial system. In the future, real-time temperature estimation will be incorporated into this system.
AB - Mild hyperthermia is increasingly important for the activation of temperature-sensitive drug delivery vehicles. Noninvasive ultrasound thermometry based on a 2-D speckle tracking algorithm was examined in this study. Here, a commercial ultrasound scanner, a customized co-linear array transducer, and a controlling PC system were used to generate mild hyperthermia. Because the co-linear array transducer is capable of both therapy and imaging at widely separated frequencies, RF image frames were acquired during therapeutic insonation and then exported for off-line analysis. For in vivo studies in a mouse model, before temperature estimation, motion correction was applied between a reference RF frame and subsequent RF frames. Both in vitro and in vivo experiments were examined; in the in vitro and in vivo studies, the average temperature error had a standard deviation of 0.7°C and 0.8°C, respectively. The application of motion correction improved the accuracy of temperature estimation, where the error range was -1.9 to 4.5°C without correction compared with -1.1 to 1.0°C following correction. This study demonstrates the feasibility of combining therapy and monitoring using a commercial system. In the future, real-time temperature estimation will be incorporated into this system.
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U2 - 10.1109/TUFFC.2010.1741
DO - 10.1109/TUFFC.2010.1741
M3 - Article
C2 - 21156363
AN - SCOPUS:78650409810
VL - 57
SP - 2671
EP - 2684
JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
SN - 0885-3010
IS - 12
M1 - 5610553
ER -