Noninvasive multimodality imaging techniques to assess Kaposi's sarcoma

Amir H. Gandjbakhche, Abby Vogel, Franck Amyot, Victor Chernomordik, Stavros Demos, Karen Aleman, Richard Little, Robert Yarchoan, Moinuddin Hassan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We evaluated three non-invasive method, thermography, laser Doppler imaging and near infrared multi-spectral imaging to quantitatively assess parameters of vascularity in Kaposi's sarcoma. The KS lesion generally has increased temperature, blood velocity and blood deoxy-hemoglobin. There is a strong correlation between temperature and blood velocity (R= 81, p<0.001). After treatment with experimental drug (liposomal doxorubicin and interleukin-12), temperature, blood velocity, blood volume and deoxy-hemoglobin of the lesions are reduced from the baseline at week 18. The techniques are objective, easy to perform, and appear to be very sensitive in assessing improvement in the lesions upon administration of therapy.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages694-696
Number of pages3
Volume7 VOLS
StatePublished - 2005
Externally publishedYes
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: Sep 1 2005Sep 4 2005

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period9/1/059/4/05

Keywords

  • Angiogenesis
  • Laser Doppler imaging
  • Multi-modality imaging
  • Multi-spectral imaging
  • Temperature

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Gandjbakhche, A. H., Vogel, A., Amyot, F., Chernomordik, V., Demos, S., Aleman, K., Little, R., Yarchoan, R., & Hassan, M. (2005). Noninvasive multimodality imaging techniques to assess Kaposi's sarcoma. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 7 VOLS, pp. 694-696). [1616508]