Noninvasive measurement of renal hemodynamic functions using gadolinium enhanced magnetic resonance imaging

C. L. Dumoulin, M. H. Buonocore, L. R. Opsahl, Richard W Katzberg, R. D. Darrow, T. W. Morris, C. Batey

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

A technique for the assessment of single kidney hemodynamic functions utilizing a novel MR pulse sequence in conjunction with MR contrast material administration is described. Renal extraction fraction (EF) is derived by measuring the concentration of the incoming contrast agent in the renal artery and the outgoing concentration in the renal vein. The glomerular filtration rate (GFR) can then be determined by the product of EF and renal plasma flow. A modified inversion recovery MR pulse sequence is used to measure the T1 of moving blood. This pulse sequence uses a spatially nonselective inversion pulse. A series of small flip angle detection pulses are then used to monitor the recovery of longitudinal spin magnetization in an image plane intersecting the renal vessels. The recovery rate is measured in each vessel and the T1 of blood determined. These T1 measurements are then used to determine the ratio of contrast concentration in the renal arteries and veins. Blood flow measurements can be obtained simultaneously with T1 measurements by inserting flow-encoding magnetic field gradients into the pulse sequence. Preliminary results in human volunteers suggest the feasibility of noninvasively determining hemodynamic functions with magnetic resonance.

Original languageEnglish (US)
Pages (from-to)370-378
Number of pages9
JournalMagnetic Resonance in Medicine
Volume32
Issue number3
StatePublished - 1994

Fingerprint

Gadolinium
Renal Veins
Hemodynamics
Magnetic Resonance Imaging
Renal Artery
Kidney
Contrast Media
Renal Plasma Flow
Magnetic Fields
Glomerular Filtration Rate
Blood Vessels
Volunteers
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Dumoulin, C. L., Buonocore, M. H., Opsahl, L. R., Katzberg, R. W., Darrow, R. D., Morris, T. W., & Batey, C. (1994). Noninvasive measurement of renal hemodynamic functions using gadolinium enhanced magnetic resonance imaging. Magnetic Resonance in Medicine, 32(3), 370-378.

Noninvasive measurement of renal hemodynamic functions using gadolinium enhanced magnetic resonance imaging. / Dumoulin, C. L.; Buonocore, M. H.; Opsahl, L. R.; Katzberg, Richard W; Darrow, R. D.; Morris, T. W.; Batey, C.

In: Magnetic Resonance in Medicine, Vol. 32, No. 3, 1994, p. 370-378.

Research output: Contribution to journalArticle

Dumoulin, CL, Buonocore, MH, Opsahl, LR, Katzberg, RW, Darrow, RD, Morris, TW & Batey, C 1994, 'Noninvasive measurement of renal hemodynamic functions using gadolinium enhanced magnetic resonance imaging', Magnetic Resonance in Medicine, vol. 32, no. 3, pp. 370-378.
Dumoulin CL, Buonocore MH, Opsahl LR, Katzberg RW, Darrow RD, Morris TW et al. Noninvasive measurement of renal hemodynamic functions using gadolinium enhanced magnetic resonance imaging. Magnetic Resonance in Medicine. 1994;32(3):370-378.
Dumoulin, C. L. ; Buonocore, M. H. ; Opsahl, L. R. ; Katzberg, Richard W ; Darrow, R. D. ; Morris, T. W. ; Batey, C. / Noninvasive measurement of renal hemodynamic functions using gadolinium enhanced magnetic resonance imaging. In: Magnetic Resonance in Medicine. 1994 ; Vol. 32, No. 3. pp. 370-378.
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