Noninvasive infrared imaging for quantitative assessment of tumor vasculature and response to therapy

Moinuddin Hassan, David Hattery, Abby Vogel, Victor Chernomordik, Stavros Demos, Karen Aleman, Richard Little, Robert Yarchoan, Amir H. Gandjbakhche

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

In this study we are investigating three infrared imaging techniques, thermography, multispectral imaging and Laser Doppler imaging (LDI) to assess parameters of vascularity in lesions of Kaposi's sarcoma (KS) and response to therapy. Thermography, multispectral imaging and LDI were recorded over the lesion and compare to normal skin either adjacent to the lesion or on the contralateral side. The KS lesions generally had increased temperature, blood volume (as measured by multispectral imaging) and blood flux (as measured by LDI) as compare to normal skin. After the treatment with experimental anti-KS drug, temperature, blood volume and blood flow of the lesion were significantly reduced from the baseline. These techniques hold promise to assess physiological parameter in KS lesion and their changes with therapy.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages1200-1202
Number of pages3
Volume26 II
StatePublished - 2004
Externally publishedYes
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Other

OtherConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
CountryUnited States
CitySan Francisco, CA
Period9/1/049/5/04

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Keywords

  • Angiogenesis
  • Anti-KS therapy
  • Infrared imaging
  • Kaposi's sarcoma

ASJC Scopus subject areas

  • Bioengineering

Cite this

Hassan, M., Hattery, D., Vogel, A., Chernomordik, V., Demos, S., Aleman, K., Little, R., Yarchoan, R., & Gandjbakhche, A. H. (2004). Noninvasive infrared imaging for quantitative assessment of tumor vasculature and response to therapy. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 26 II, pp. 1200-1202)