Abstract
γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous γδ T-cell lymphoma (PCGD-TCL). However, whether other anatomic sites may also be involved and whether they represent a spectrum of the same disease are not well studied. The lack of T-cell receptor (TCR)β expression has been used to infer a γδ origin when other methods are not available. We studied 35 T-cell tumors suspected to be γδ TCL using monoclonal antibodies reactive with TCR δ or γ in paraffin sections. We were able to confirm γδ chain expression in 22 of 35 cases. We identified 8 PCGD-TCLs, 6 HSTLs, and 8 γδ TCLs without hepatosplenic or cutaneous involvement involving mainly extranodal sites. Two such cases were classified as enteropathy- associated T-cell lymphoma, type II. The other γδ TCL presented in the intestine, lung, tongue, orbit, and lymph node. In addition, we observed 13 cases with mainly extranodal involvement that lacked any TCR expression ("TCR silent"). In all cases, a natural killer cell origin was excluded. In conclusion, the lack of TCRβ expression does not always predict γδ-T-cell derivation, as TCR silent cases may be found. The recognition of γδ TCL presenting in extranodal sites other than skin and liver/spleen expands the clinical spectrum of these tumors. However, non-HSTL γδ TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1214-1225 |
| Number of pages | 12 |
| Journal | American Journal of Surgical Pathology |
| Volume | 35 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2011 |
| Externally published | Yes |
Fingerprint
Keywords
- αβ T-cell receptor
- γδ T-cell lymphomas
- γδ T-cell receptor
- cutaneous γδ T-cell lymphoma
- hepatosplenic T-cell lymphoma
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Surgery
Cite this
Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation. / Garcia-Herrera, Adriana; Song, Joo Y.; Chuang, Shih Sung; Villamor, Neus; Colomo, Luis; Pittaluga, Stefania; Alvaro, Tomas; Rozman, Maria; De Anda Gonzalez, Jazmin; Arrunategui, Ana Maria; Fernandez, Eva; Gonzalvo, Elena; Estrach, Teresa; Colomer, Dolors; Raffeld, Mark; Gaulard, Philippe; Campo, Elias; Jaffe, Elaine S.; Martinez, Antonio.
In: American Journal of Surgical Pathology, Vol. 35, No. 8, 08.2011, p. 1214-1225.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
AU - Garcia-Herrera, Adriana
AU - Song, Joo Y.
AU - Chuang, Shih Sung
AU - Villamor, Neus
AU - Colomo, Luis
AU - Pittaluga, Stefania
AU - Alvaro, Tomas
AU - Rozman, Maria
AU - De Anda Gonzalez, Jazmin
AU - Arrunategui, Ana Maria
AU - Fernandez, Eva
AU - Gonzalvo, Elena
AU - Estrach, Teresa
AU - Colomer, Dolors
AU - Raffeld, Mark
AU - Gaulard, Philippe
AU - Campo, Elias
AU - Jaffe, Elaine S.
AU - Martinez, Antonio
PY - 2011/8
Y1 - 2011/8
N2 - γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous γδ T-cell lymphoma (PCGD-TCL). However, whether other anatomic sites may also be involved and whether they represent a spectrum of the same disease are not well studied. The lack of T-cell receptor (TCR)β expression has been used to infer a γδ origin when other methods are not available. We studied 35 T-cell tumors suspected to be γδ TCL using monoclonal antibodies reactive with TCR δ or γ in paraffin sections. We were able to confirm γδ chain expression in 22 of 35 cases. We identified 8 PCGD-TCLs, 6 HSTLs, and 8 γδ TCLs without hepatosplenic or cutaneous involvement involving mainly extranodal sites. Two such cases were classified as enteropathy- associated T-cell lymphoma, type II. The other γδ TCL presented in the intestine, lung, tongue, orbit, and lymph node. In addition, we observed 13 cases with mainly extranodal involvement that lacked any TCR expression ("TCR silent"). In all cases, a natural killer cell origin was excluded. In conclusion, the lack of TCRβ expression does not always predict γδ-T-cell derivation, as TCR silent cases may be found. The recognition of γδ TCL presenting in extranodal sites other than skin and liver/spleen expands the clinical spectrum of these tumors. However, non-HSTL γδ TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study.
AB - γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous γδ T-cell lymphoma (PCGD-TCL). However, whether other anatomic sites may also be involved and whether they represent a spectrum of the same disease are not well studied. The lack of T-cell receptor (TCR)β expression has been used to infer a γδ origin when other methods are not available. We studied 35 T-cell tumors suspected to be γδ TCL using monoclonal antibodies reactive with TCR δ or γ in paraffin sections. We were able to confirm γδ chain expression in 22 of 35 cases. We identified 8 PCGD-TCLs, 6 HSTLs, and 8 γδ TCLs without hepatosplenic or cutaneous involvement involving mainly extranodal sites. Two such cases were classified as enteropathy- associated T-cell lymphoma, type II. The other γδ TCL presented in the intestine, lung, tongue, orbit, and lymph node. In addition, we observed 13 cases with mainly extranodal involvement that lacked any TCR expression ("TCR silent"). In all cases, a natural killer cell origin was excluded. In conclusion, the lack of TCRβ expression does not always predict γδ-T-cell derivation, as TCR silent cases may be found. The recognition of γδ TCL presenting in extranodal sites other than skin and liver/spleen expands the clinical spectrum of these tumors. However, non-HSTL γδ TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study.
KW - αβ T-cell receptor
KW - γδ T-cell lymphomas
KW - γδ T-cell receptor
KW - cutaneous γδ T-cell lymphoma
KW - hepatosplenic T-cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=79961077697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961077697&partnerID=8YFLogxK
U2 - 10.1097/PAS.0b013e31822067d1
DO - 10.1097/PAS.0b013e31822067d1
M3 - Article
C2 - 21753698
AN - SCOPUS:79961077697
VL - 35
SP - 1214
EP - 1225
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
SN - 0147-5185
IS - 8
ER -