Nongenomic effects of estradiol on aggression under short day photoperiods

Sarah A. Laredo, Rosalina Villalon Landeros, James C. Dooley, Michael Q. Steinman, Veronica Orr, Andrea L. Silva, Katie K. Crean, Cindee F. Robles, Brian C. Trainor

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In several vertebrate species, the effects of estrogens on male aggressive behavior can be modulated by environmental cues. In song sparrows and rodents, estrogens modulate aggression in the nonbreeding season or winter-like short days, respectively. The behavioral effects of estrogens are rapid, which generally is considered indicative of nongenomic processes. The current study further examined the hypothesis that estradiol acts nongenomically under short days by utilizing a protein synthesis inhibitor, cycloheximide (CX). Mice were housed in either short or long day photoperiods, and treated with an aromatase inhibitor. One hour before resident-intruder testing mice were injected with either CX or saline vehicle, and 30. min later were treated orally with either cyclodextrin conjugated estradiol or vehicle. Under short days, mice treated with estradiol showed a rapid decrease in aggressive behavior, independent of CX administration. CX alone had no effect on aggression. These results show that protein synthesis is not required for the rapid effects of estradiol on aggression, strongly suggesting that these effects are mediated by nongenomic processes. We also showed that estradiol suppressed c-fos immunoreactivity in the caudal bed nucleus of the stria terminalis under short days. No effects of estradiol on behavior or c-fos expression were observed in mice housed under long days. Previously we had also demonstrated that cage bedding influenced the directional effects of estrogens on aggression. Here, we show that the phenomenon of rapid action of estradiol on aggression under short days is a robust result that generalizes to different bedding conditions.

Original languageEnglish (US)
Pages (from-to)557-565
Number of pages9
JournalHormones and Behavior
Volume64
Issue number3
DOIs
StatePublished - Aug 2013

Fingerprint

Photoperiod
Aggression
Estradiol
Cycloheximide
Estrogens
Sparrows
Septal Nuclei
Aromatase Inhibitors
Protein Synthesis Inhibitors
Cyclodextrins
Music
Cues
Vertebrates
Rodentia
Proteins

Keywords

  • Aggression
  • Estradiol
  • Nongenomic
  • Photoperiod

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Laredo, S. A., Villalon Landeros, R., Dooley, J. C., Steinman, M. Q., Orr, V., Silva, A. L., ... Trainor, B. C. (2013). Nongenomic effects of estradiol on aggression under short day photoperiods. Hormones and Behavior, 64(3), 557-565. https://doi.org/10.1016/j.yhbeh.2013.06.002

Nongenomic effects of estradiol on aggression under short day photoperiods. / Laredo, Sarah A.; Villalon Landeros, Rosalina; Dooley, James C.; Steinman, Michael Q.; Orr, Veronica; Silva, Andrea L.; Crean, Katie K.; Robles, Cindee F.; Trainor, Brian C.

In: Hormones and Behavior, Vol. 64, No. 3, 08.2013, p. 557-565.

Research output: Contribution to journalArticle

Laredo, SA, Villalon Landeros, R, Dooley, JC, Steinman, MQ, Orr, V, Silva, AL, Crean, KK, Robles, CF & Trainor, BC 2013, 'Nongenomic effects of estradiol on aggression under short day photoperiods', Hormones and Behavior, vol. 64, no. 3, pp. 557-565. https://doi.org/10.1016/j.yhbeh.2013.06.002
Laredo SA, Villalon Landeros R, Dooley JC, Steinman MQ, Orr V, Silva AL et al. Nongenomic effects of estradiol on aggression under short day photoperiods. Hormones and Behavior. 2013 Aug;64(3):557-565. https://doi.org/10.1016/j.yhbeh.2013.06.002
Laredo, Sarah A. ; Villalon Landeros, Rosalina ; Dooley, James C. ; Steinman, Michael Q. ; Orr, Veronica ; Silva, Andrea L. ; Crean, Katie K. ; Robles, Cindee F. ; Trainor, Brian C. / Nongenomic effects of estradiol on aggression under short day photoperiods. In: Hormones and Behavior. 2013 ; Vol. 64, No. 3. pp. 557-565.
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