Noncollagenous bone proteins in experimental rickets in the rat

Shlomo Wientroub, Larry W. Fisher, A Hari Reddi, John D. Termine

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Rats were raised in the absence of vitamin D in utero and throughout post-fetal life and neither 1,25-dihydroxyvitamin D3 nor related metabolites were detected in serums. No changes were observed in the relative amount of extractable noncollagenous bone proteins (NCP) in rachitic compared to vitamin-D-repleted animals. As expected, the relative levels of the mineral-bound, serum-derived albumin and α2-HS glycoprotein were unaffected in bones of rachitic animals. Interestingly, the vitamin D deficiency also did not have dramatic effects on several bone cell-derived noncollagenous proteins including: bone proteoglycans I & 11, bone sialoprotein li osteonectin, and osteocalcin. In contrast to the proteoglycans, the bone sialoprotein II and osteonectin were found in the nonmineral compartment of the rachitic animals, presumably bound to the wide osteoid seam.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume74
Issue number2
DOIs
StatePublished - Apr 1987
Externally publishedYes

Keywords

  • bone sialoprotein
  • noncollagenous proteins
  • osteocalcin
  • osteonectin
  • proteoglycan
  • rickets
  • vitamin D

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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