Nonalcoholic steatohepatitis and the metabolic syndrome

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a major form of chronic liver disease in adults and children. It is one of the consequences of the current obesity epidemic, and can progress to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and progressive fibrosis, ultimately leading to cirrhosis and end-stage liver disease. The factors implicated in this progression are poorly understood. NASH is closely associated with obesity and the metabolic syndrome. Recent studies emphasize the role of insulin resistance, oxidative stress, lipid peroxidation, and cytokine release in the development of NASH. This review summarizes the current knowledge on the etiology and pathomechanism of NASH and the role of the metabolic syndrome in NASH development.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalMetabolic Syndrome and Related Disorders
Volume6
Issue number1
DOIs
StatePublished - Mar 1 2008

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Fibrosis
Obesity
End Stage Liver Disease
Lipid Peroxidation
Insulin Resistance
Non-alcoholic Fatty Liver Disease
Liver Diseases
Oxidative Stress
Chronic Disease
Cytokines
Inflammation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Nonalcoholic steatohepatitis and the metabolic syndrome. / Jiang, Xiaosong; Torok, Natalia J.

In: Metabolic Syndrome and Related Disorders, Vol. 6, No. 1, 01.03.2008, p. 1-7.

Research output: Contribution to journalArticle

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