Nonalcoholic steatohepatitis and the metabolic syndrome

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38 Scopus citations


Nonalcoholic fatty liver disease (NAFLD) is a major form of chronic liver disease in adults and children. It is one of the consequences of the current obesity epidemic, and can progress to nonalcoholic steatohepatitis (NASH), characterized by steatosis, inflammation, and progressive fibrosis, ultimately leading to cirrhosis and end-stage liver disease. The factors implicated in this progression are poorly understood. NASH is closely associated with obesity and the metabolic syndrome. Recent studies emphasize the role of insulin resistance, oxidative stress, lipid peroxidation, and cytokine release in the development of NASH. This review summarizes the current knowledge on the etiology and pathomechanism of NASH and the role of the metabolic syndrome in NASH development.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalMetabolic Syndrome and Related Disorders
Issue number1
StatePublished - Mar 1 2008

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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