Abstract
Background and Aim: Nonalcoholic fatty liver disease (NAFLD) is increasingly common worldwide. We explored clinical, laboratory, and histological features of NAFLD as well as risk factors for histologically advanced disease among under-represented ethno-racial groups. Methods: Patient records from one NAFLD clinic in California from 1998-2008 were reviewed. Biopsies were graded using Brunt criteria by a hepatopathologist blinded to clinical data. We used multivariate logistic regression to assess associations between ethno-racial group and histological severity of NAFLD, while controlling for other factors. Results: We identified 90 biopsy-proven cases of NAFLD. Mean age was 49years (standard deviation [SD]=11.6), and half were female. 52% of patients were Caucasian, 20% Latino-American, 18% Asian-American, and 10% Middle Eastern-American. There were significant differences among groups with respect to age, weight, body mass index (BMI), and grade of hepatic steatosis (all P<0.05). In multivariate analysis, older age was associated with severe (Brunt≥2) inflammation (odds ratio [OR] 1.1, P=0.002) and severe (Brunt≥3) fibrosis (OR 1.2, P=0.001), diabetes was associated with severe inflammation (OR 3.18, P=0.07) and severe fibrosis (OR 8.81, P=0.002), and increased BMI was associated with severe fibrosis (OR 2.43, P=0.07). Additionally, compared to Caucasians, Asian-Americans showed a trend toward an association with severe (Brunt>2) steatosis (OR 3.83, P=0.08) and severe inflammation (OR 5.42, P=0.06). Conclusions: The findings from this ethno-racially diverse clinic-based cohort are consistent with prior studies and also suggest that Asian-Americans may be at risk for advanced NAFLD. This may have implications for the prevention, evaluation, and treatment of patients with NAFLD that merit further study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 501-509 |
| Number of pages | 9 |
| Journal | Journal of Gastroenterology and Hepatology (Australia) |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2011 |
| Externally published | Yes |
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Keywords
- Cirrhosis
- Ethnic groups
- Fatty liver
- Histopathology
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
Nonalcoholic fatty liver disease across ethno-racial groups : Do Asian-American adults represent a new at-risk population? / Tabibian, James H.; Lazo, Mariana; Durazo, Francisco A.; Yeh, Hsin Chieh; Tong, Myron J.; Clark, Jeanne M.
In: Journal of Gastroenterology and Hepatology (Australia), Vol. 26, No. 3, 2011, p. 501-509.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nonalcoholic fatty liver disease across ethno-racial groups
T2 - Do Asian-American adults represent a new at-risk population?
AU - Tabibian, James H.
AU - Lazo, Mariana
AU - Durazo, Francisco A.
AU - Yeh, Hsin Chieh
AU - Tong, Myron J.
AU - Clark, Jeanne M.
PY - 2011
Y1 - 2011
N2 - Background and Aim: Nonalcoholic fatty liver disease (NAFLD) is increasingly common worldwide. We explored clinical, laboratory, and histological features of NAFLD as well as risk factors for histologically advanced disease among under-represented ethno-racial groups. Methods: Patient records from one NAFLD clinic in California from 1998-2008 were reviewed. Biopsies were graded using Brunt criteria by a hepatopathologist blinded to clinical data. We used multivariate logistic regression to assess associations between ethno-racial group and histological severity of NAFLD, while controlling for other factors. Results: We identified 90 biopsy-proven cases of NAFLD. Mean age was 49years (standard deviation [SD]=11.6), and half were female. 52% of patients were Caucasian, 20% Latino-American, 18% Asian-American, and 10% Middle Eastern-American. There were significant differences among groups with respect to age, weight, body mass index (BMI), and grade of hepatic steatosis (all P<0.05). In multivariate analysis, older age was associated with severe (Brunt≥2) inflammation (odds ratio [OR] 1.1, P=0.002) and severe (Brunt≥3) fibrosis (OR 1.2, P=0.001), diabetes was associated with severe inflammation (OR 3.18, P=0.07) and severe fibrosis (OR 8.81, P=0.002), and increased BMI was associated with severe fibrosis (OR 2.43, P=0.07). Additionally, compared to Caucasians, Asian-Americans showed a trend toward an association with severe (Brunt>2) steatosis (OR 3.83, P=0.08) and severe inflammation (OR 5.42, P=0.06). Conclusions: The findings from this ethno-racially diverse clinic-based cohort are consistent with prior studies and also suggest that Asian-Americans may be at risk for advanced NAFLD. This may have implications for the prevention, evaluation, and treatment of patients with NAFLD that merit further study.
AB - Background and Aim: Nonalcoholic fatty liver disease (NAFLD) is increasingly common worldwide. We explored clinical, laboratory, and histological features of NAFLD as well as risk factors for histologically advanced disease among under-represented ethno-racial groups. Methods: Patient records from one NAFLD clinic in California from 1998-2008 were reviewed. Biopsies were graded using Brunt criteria by a hepatopathologist blinded to clinical data. We used multivariate logistic regression to assess associations between ethno-racial group and histological severity of NAFLD, while controlling for other factors. Results: We identified 90 biopsy-proven cases of NAFLD. Mean age was 49years (standard deviation [SD]=11.6), and half were female. 52% of patients were Caucasian, 20% Latino-American, 18% Asian-American, and 10% Middle Eastern-American. There were significant differences among groups with respect to age, weight, body mass index (BMI), and grade of hepatic steatosis (all P<0.05). In multivariate analysis, older age was associated with severe (Brunt≥2) inflammation (odds ratio [OR] 1.1, P=0.002) and severe (Brunt≥3) fibrosis (OR 1.2, P=0.001), diabetes was associated with severe inflammation (OR 3.18, P=0.07) and severe fibrosis (OR 8.81, P=0.002), and increased BMI was associated with severe fibrosis (OR 2.43, P=0.07). Additionally, compared to Caucasians, Asian-Americans showed a trend toward an association with severe (Brunt>2) steatosis (OR 3.83, P=0.08) and severe inflammation (OR 5.42, P=0.06). Conclusions: The findings from this ethno-racially diverse clinic-based cohort are consistent with prior studies and also suggest that Asian-Americans may be at risk for advanced NAFLD. This may have implications for the prevention, evaluation, and treatment of patients with NAFLD that merit further study.
KW - Cirrhosis
KW - Ethnic groups
KW - Fatty liver
KW - Histopathology
UR - http://www.scopus.com/inward/record.url?scp=79951624285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951624285&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1746.2010.06443.x
DO - 10.1111/j.1440-1746.2010.06443.x
M3 - Article
C2 - 21332546
AN - SCOPUS:79951624285
VL - 26
SP - 501
EP - 509
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 3
ER -