Non-radiation-related osteonecrosis of the jaws in dogs: 14 cases (1996-2014)

Santiago Peralta, Boaz Arzi, Ana Nemec, Milinda J. Lommer, Frank J.M. Verstraete

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Osteonecrosis of the jaws (ONJ) is an entity of major clinical impact characterized by chronically exposed necrotic mandibular or maxillary bone. Its clinicopathological characteristics and possible inciting or risk factors are well described in humans but only anecdotally reported in dogs. Treatment modalities and outcome vary depending on the inciting factors involved and the extent and severity of the lesions. The objectives of this study were to retrospectively describe the clinicopathological features of non-radiation-related ONJ in a series of 14 dogs, identify possible inciting or risk factors, and report on the surgical treatment and outcome. For all patients, the medical records were used to collect information regarding signalment, clinical signs, characteristics of the oral, jaw and dental lesions, diagnostic imaging findings, histopathological and microbiological analysis, treatment performed, and outcome. The data collected showed that non-radiation-related ONJ appears to be an infrequent clinical entity but of significant impact in dogs; that a history of systemic antibiotics and dental disease is common among affected dogs; that previous dental extractions are commonly associated with ONJ sites; that using a systematic diagnostic approach is essential for diagnosis; and that thorough surgical debridement combined with a course of oral antibiotics was effective in the described dogs affected by advanced non-radiation-related ONJ.

Original languageEnglish (US)
Article number7
JournalFrontiers in Veterinary Science
Issue numberMAY
StatePublished - May 5 2015


  • Dogs
  • Mandible
  • Maxilla
  • Osteomyelitis
  • Osteonecrosis of the jaws

ASJC Scopus subject areas

  • veterinary(all)


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