Abstract
Osteonecrosis of the jaws (ONJ) is an entity of major clinical impact characterized by chronically exposed necrotic mandibular or maxillary bone. Its clinicopathological characteristics and possible inciting or risk factors are well described in humans but only anecdotally reported in dogs. Treatment modalities and outcome vary depending on the inciting factors involved and the extent and severity of the lesions. The objectives of this study were to retrospectively describe the clinicopathological features of non-radiation-related ONJ in a series of 14 dogs, identify possible inciting or risk factors, and report on the surgical treatment and outcome. For all patients, the medical records were used to collect information regarding signalment, clinical signs, characteristics of the oral, jaw and dental lesions, diagnostic imaging findings, histopathological and microbiological analysis, treatment performed, and outcome. The data collected showed that non-radiation-related ONJ appears to be an infrequent clinical entity but of significant impact in dogs; that a history of systemic antibiotics and dental disease is common among affected dogs; that previous dental extractions are commonly associated with ONJ sites; that using a systematic diagnostic approach is essential for diagnosis; and that thorough surgical debridement combined with a course of oral antibiotics was effective in the described dogs affected by advanced non-radiation-related ONJ.
| Original language | English (US) |
|---|---|
| Article number | 7 |
| Journal | Frontiers in Veterinary Science |
| Volume | 2 |
| Issue number | MAY |
| DOIs | |
| State | Published - May 5 2015 |
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Keywords
- Dogs
- Mandible
- Maxilla
- Osteomyelitis
- Osteonecrosis of the jaws
ASJC Scopus subject areas
- veterinary(all)
Cite this
Non-radiation-related osteonecrosis of the jaws in dogs : 14 cases (1996-2014). / Peralta, Santiago; Arzi, Boaz; Nemec, Ana; Lommer, Milinda J.; Verstraete, Frank J.
In: Frontiers in Veterinary Science, Vol. 2, No. MAY, 7, 05.05.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Non-radiation-related osteonecrosis of the jaws in dogs
T2 - 14 cases (1996-2014)
AU - Peralta, Santiago
AU - Arzi, Boaz
AU - Nemec, Ana
AU - Lommer, Milinda J.
AU - Verstraete, Frank J
PY - 2015/5/5
Y1 - 2015/5/5
N2 - Osteonecrosis of the jaws (ONJ) is an entity of major clinical impact characterized by chronically exposed necrotic mandibular or maxillary bone. Its clinicopathological characteristics and possible inciting or risk factors are well described in humans but only anecdotally reported in dogs. Treatment modalities and outcome vary depending on the inciting factors involved and the extent and severity of the lesions. The objectives of this study were to retrospectively describe the clinicopathological features of non-radiation-related ONJ in a series of 14 dogs, identify possible inciting or risk factors, and report on the surgical treatment and outcome. For all patients, the medical records were used to collect information regarding signalment, clinical signs, characteristics of the oral, jaw and dental lesions, diagnostic imaging findings, histopathological and microbiological analysis, treatment performed, and outcome. The data collected showed that non-radiation-related ONJ appears to be an infrequent clinical entity but of significant impact in dogs; that a history of systemic antibiotics and dental disease is common among affected dogs; that previous dental extractions are commonly associated with ONJ sites; that using a systematic diagnostic approach is essential for diagnosis; and that thorough surgical debridement combined with a course of oral antibiotics was effective in the described dogs affected by advanced non-radiation-related ONJ.
AB - Osteonecrosis of the jaws (ONJ) is an entity of major clinical impact characterized by chronically exposed necrotic mandibular or maxillary bone. Its clinicopathological characteristics and possible inciting or risk factors are well described in humans but only anecdotally reported in dogs. Treatment modalities and outcome vary depending on the inciting factors involved and the extent and severity of the lesions. The objectives of this study were to retrospectively describe the clinicopathological features of non-radiation-related ONJ in a series of 14 dogs, identify possible inciting or risk factors, and report on the surgical treatment and outcome. For all patients, the medical records were used to collect information regarding signalment, clinical signs, characteristics of the oral, jaw and dental lesions, diagnostic imaging findings, histopathological and microbiological analysis, treatment performed, and outcome. The data collected showed that non-radiation-related ONJ appears to be an infrequent clinical entity but of significant impact in dogs; that a history of systemic antibiotics and dental disease is common among affected dogs; that previous dental extractions are commonly associated with ONJ sites; that using a systematic diagnostic approach is essential for diagnosis; and that thorough surgical debridement combined with a course of oral antibiotics was effective in the described dogs affected by advanced non-radiation-related ONJ.
KW - Dogs
KW - Mandible
KW - Maxilla
KW - Osteomyelitis
KW - Osteonecrosis of the jaws
UR - http://www.scopus.com/inward/record.url?scp=85018444452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018444452&partnerID=8YFLogxK
U2 - 10.3389/fvets.2015.00007
DO - 10.3389/fvets.2015.00007
M3 - Article
AN - SCOPUS:85018444452
VL - 2
JO - Frontiers in Veterinary Science
JF - Frontiers in Veterinary Science
SN - 2297-1769
IS - MAY
M1 - 7
ER -