Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1

Cheryl M. Coffin, Jamie Cassity, David Viskochil, R Randall, Karen Albritton

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

It is well known that children and young adults with neurofibromatosis type 1 (NF1) have a higher risk for non-neurogenic sarcomas than the general population, in addition to an increased risk for malignant peripheral nerve sheath tumor. When non-neurogenic sarcomas occur in early childhood, a subsequent malignant peripheral nerve sheath tumor can occur as a second malignant neoplasm, especially after alkylating agent chemotherapy and irradiation. This report includes the clinicopathologic features of nonneurogenic sarcomas and secondary malignant peripheral nerve sheath tumor in the context of four cases of NF1. The purpose is to emphasize that early diagnosis of NF1 and recognition of potential manifestations of non-neurogenic sarcomas are important for clinical care of these patients and their families.

Original languageEnglish (US)
Pages (from-to)40-43
Number of pages4
JournalAmerican Journal of Medical Genetics
Volume127 A
Issue number1
StatePublished - May 15 2004
Externally publishedYes

Fingerprint

Neurofibromatosis 1
Sarcoma
Young Adult
Neurilemmoma
Second Primary Neoplasms
Alkylating Agents
Early Diagnosis
Patient Care
Drug Therapy
Population

Keywords

  • Malignant peripheral nerve sheath tumor
  • Neurofibromatosis type 1
  • Rhabdomyosarcoma
  • Sarcomas
  • Secondary malignant neoplasm

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1. / Coffin, Cheryl M.; Cassity, Jamie; Viskochil, David; Randall, R; Albritton, Karen.

In: American Journal of Medical Genetics, Vol. 127 A, No. 1, 15.05.2004, p. 40-43.

Research output: Contribution to journalArticle

Coffin, CM, Cassity, J, Viskochil, D, Randall, R & Albritton, K 2004, 'Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1', American Journal of Medical Genetics, vol. 127 A, no. 1, pp. 40-43.
Coffin, Cheryl M. ; Cassity, Jamie ; Viskochil, David ; Randall, R ; Albritton, Karen. / Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1. In: American Journal of Medical Genetics. 2004 ; Vol. 127 A, No. 1. pp. 40-43.
@article{9ef7abb8bbee48739eedb95fdf45daf1,
title = "Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1",
abstract = "It is well known that children and young adults with neurofibromatosis type 1 (NF1) have a higher risk for non-neurogenic sarcomas than the general population, in addition to an increased risk for malignant peripheral nerve sheath tumor. When non-neurogenic sarcomas occur in early childhood, a subsequent malignant peripheral nerve sheath tumor can occur as a second malignant neoplasm, especially after alkylating agent chemotherapy and irradiation. This report includes the clinicopathologic features of nonneurogenic sarcomas and secondary malignant peripheral nerve sheath tumor in the context of four cases of NF1. The purpose is to emphasize that early diagnosis of NF1 and recognition of potential manifestations of non-neurogenic sarcomas are important for clinical care of these patients and their families.",
keywords = "Malignant peripheral nerve sheath tumor, Neurofibromatosis type 1, Rhabdomyosarcoma, Sarcomas, Secondary malignant neoplasm",
author = "Coffin, {Cheryl M.} and Jamie Cassity and David Viskochil and R Randall and Karen Albritton",
year = "2004",
month = "5",
day = "15",
language = "English (US)",
volume = "127 A",
pages = "40--43",
journal = "American Journal of Medical Genetics",
issn = "1552-4825",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1

AU - Coffin, Cheryl M.

AU - Cassity, Jamie

AU - Viskochil, David

AU - Randall, R

AU - Albritton, Karen

PY - 2004/5/15

Y1 - 2004/5/15

N2 - It is well known that children and young adults with neurofibromatosis type 1 (NF1) have a higher risk for non-neurogenic sarcomas than the general population, in addition to an increased risk for malignant peripheral nerve sheath tumor. When non-neurogenic sarcomas occur in early childhood, a subsequent malignant peripheral nerve sheath tumor can occur as a second malignant neoplasm, especially after alkylating agent chemotherapy and irradiation. This report includes the clinicopathologic features of nonneurogenic sarcomas and secondary malignant peripheral nerve sheath tumor in the context of four cases of NF1. The purpose is to emphasize that early diagnosis of NF1 and recognition of potential manifestations of non-neurogenic sarcomas are important for clinical care of these patients and their families.

AB - It is well known that children and young adults with neurofibromatosis type 1 (NF1) have a higher risk for non-neurogenic sarcomas than the general population, in addition to an increased risk for malignant peripheral nerve sheath tumor. When non-neurogenic sarcomas occur in early childhood, a subsequent malignant peripheral nerve sheath tumor can occur as a second malignant neoplasm, especially after alkylating agent chemotherapy and irradiation. This report includes the clinicopathologic features of nonneurogenic sarcomas and secondary malignant peripheral nerve sheath tumor in the context of four cases of NF1. The purpose is to emphasize that early diagnosis of NF1 and recognition of potential manifestations of non-neurogenic sarcomas are important for clinical care of these patients and their families.

KW - Malignant peripheral nerve sheath tumor

KW - Neurofibromatosis type 1

KW - Rhabdomyosarcoma

KW - Sarcomas

KW - Secondary malignant neoplasm

UR - http://www.scopus.com/inward/record.url?scp=3142740145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142740145&partnerID=8YFLogxK

M3 - Article

C2 - 15103715

AN - SCOPUS:3142740145

VL - 127 A

SP - 40

EP - 43

JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

SN - 1552-4825

IS - 1

ER -