Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1

Cheryl M. Coffin, Jamie Cassity, David Viskochil, R Randall, Karen Albritton

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

It is well known that children and young adults with neurofibromatosis type 1 (NF1) have a higher risk for non-neurogenic sarcomas than the general population, in addition to an increased risk for malignant peripheral nerve sheath tumor. When non-neurogenic sarcomas occur in early childhood, a subsequent malignant peripheral nerve sheath tumor can occur as a second malignant neoplasm, especially after alkylating agent chemotherapy and irradiation. This report includes the clinicopathologic features of nonneurogenic sarcomas and secondary malignant peripheral nerve sheath tumor in the context of four cases of NF1. The purpose is to emphasize that early diagnosis of NF1 and recognition of potential manifestations of non-neurogenic sarcomas are important for clinical care of these patients and their families.

Original languageEnglish (US)
Pages (from-to)40-43
Number of pages4
JournalAmerican Journal of Medical Genetics
Volume127 A
Issue number1
StatePublished - May 15 2004
Externally publishedYes

Keywords

  • Malignant peripheral nerve sheath tumor
  • Neurofibromatosis type 1
  • Rhabdomyosarcoma
  • Sarcomas
  • Secondary malignant neoplasm

ASJC Scopus subject areas

  • Genetics(clinical)

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