Non-invasive image acquisition and advanced processing in optical bioimaging

Daniel L. Farkas; Congwu Du; Gregory W. Fisher; Christopher Lau; Wenhua Niu; Elliot S. Wachman; Richard M Levenson

doi:10.1016/S0895-6111(98)00011-1

Non-invasive image acquisition and advanced processing in optical bioimaging

Daniel L. Farkas, Congwu Du, Gregory W. Fisher, Christopher Lau, Wenhua Niu, Elliot S. Wachman, Richard M Levenson

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Light is a most versatile tool for investigating biological systems and phenomena; the range, non-destructiveness, spatial discrimination and speed of optical imaging are all important for investigating structure and function at the cellular, tissue or even whole organism level. In live biological imaging, where the technological requirements are heightened, other features of light, such as coherence and wavelength, are used to generate the additional contrast and resolution needed. We report here recent improvements in our ability to image biological specimens optically, focusing on (a) spectral resolution and the related image processing issues, and (b) tomographic three-dimensional fluorescence imaging in vivo.

Original language	English (US)
Pages (from-to)	89-102
Number of pages	14
Journal	Computerized Medical Imaging and Graphics
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/S0895-6111(98)00011-1
State	Published - Mar 1998
Externally published	Yes

Keywords

Acousto-optic tunable filters
Back-projection
Fluorescence
Fourier spectroscopy
Mesoscopy
Microscopy
Processing
Reconstruction
Spectral imaging
Tomography

ASJC Scopus subject areas

Computer Science Applications
Radiology Nuclear Medicine and imaging

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abstract = "Light is a most versatile tool for investigating biological systems and phenomena; the range, non-destructiveness, spatial discrimination and speed of optical imaging are all important for investigating structure and function at the cellular, tissue or even whole organism level. In live biological imaging, where the technological requirements are heightened, other features of light, such as coherence and wavelength, are used to generate the additional contrast and resolution needed. We report here recent improvements in our ability to image biological specimens optically, focusing on (a) spectral resolution and the related image processing issues, and (b) tomographic three-dimensional fluorescence imaging in vivo.",

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AU - Farkas, Daniel L.

AU - Du, Congwu

AU - Fisher, Gregory W.

AU - Lau, Christopher

AU - Niu, Wenhua

AU - Wachman, Elliot S.

AU - Levenson, Richard M

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KW - Acousto-optic tunable filters

KW - Back-projection

KW - Fluorescence

KW - Fourier spectroscopy

KW - Mesoscopy

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KW - Processing

KW - Reconstruction

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KW - Tomography

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Non-invasive image acquisition and advanced processing in optical bioimaging

Abstract

Keywords

ASJC Scopus subject areas

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