Non-invasive image acquisition and advanced processing in optical bioimaging

Daniel L. Farkas, Congwu Du, Gregory W. Fisher, Christopher Lau, Wenhua Niu, Elliot S. Wachman, Richard M Levenson

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

Light is a most versatile tool for investigating biological systems and phenomena; the range, non-destructiveness, spatial discrimination and speed of optical imaging are all important for investigating structure and function at the cellular, tissue or even whole organism level. In live biological imaging, where the technological requirements are heightened, other features of light, such as coherence and wavelength, are used to generate the additional contrast and resolution needed. We report here recent improvements in our ability to image biological specimens optically, focusing on (a) spectral resolution and the related image processing issues, and (b) tomographic three-dimensional fluorescence imaging in vivo.

Original languageEnglish (US)
Pages (from-to)89-102
Number of pages14
JournalComputerized Medical Imaging and Graphics
Volume22
Issue number2
DOIs
StatePublished - Mar 1998
Externally publishedYes

Keywords

  • Acousto-optic tunable filters
  • Back-projection
  • Fluorescence
  • Fourier spectroscopy
  • Mesoscopy
  • Microscopy
  • Processing
  • Reconstruction
  • Spectral imaging
  • Tomography

ASJC Scopus subject areas

  • Computer Science Applications
  • Radiology Nuclear Medicine and imaging

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