Abstract
The agriculture and food industries have an opportunity to change the future of food production by providing foods containing non-essential dietary factors (NEDFs) that improve health beyond a freedom from disease. In order to accomplish this in a safe and tune-effective manner, however, each NEDF needs to be tested on a number of levels before it is incorporated into foods. In vitro assays are useful for discovering potential beneficial NEDFS, but in vivo studies are needed to both confirm positive effects and to detect negative effects. The genetic and metabolic similarities between humans and Caenorhabditis elegans, combined with the ease with which this nematode can be manipulated in the laboratory make it an attractive candidate to fulfill the role of an early stage in vivo model. Measuring the lifespan of C. elegans cultured in the presence of a range of concentrations of a NEDF would be of both mechanistic and strategic value in identifying those NEDFs that warrant further testing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1802-1805 |
| Number of pages | 4 |
| Journal | Journal of the Science of Food and Agriculture |
| Volume | 87 |
| Issue number | 10 |
| DOIs | |
| State | Published - Aug 15 2007 |
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Keywords
- Caenorhabditis elegans
- Health
- Lifespan
- Non-essential dietary factors
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Food Science
- Chemistry (miscellaneous)
Cite this
Non-essential dietary factors : From test tube to lifespan. / Hillyard, S. Luke; German, J. Bruce.
In: Journal of the Science of Food and Agriculture, Vol. 87, No. 10, 15.08.2007, p. 1802-1805.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Non-essential dietary factors
T2 - From test tube to lifespan
AU - Hillyard, S. Luke
AU - German, J. Bruce
PY - 2007/8/15
Y1 - 2007/8/15
N2 - The agriculture and food industries have an opportunity to change the future of food production by providing foods containing non-essential dietary factors (NEDFs) that improve health beyond a freedom from disease. In order to accomplish this in a safe and tune-effective manner, however, each NEDF needs to be tested on a number of levels before it is incorporated into foods. In vitro assays are useful for discovering potential beneficial NEDFS, but in vivo studies are needed to both confirm positive effects and to detect negative effects. The genetic and metabolic similarities between humans and Caenorhabditis elegans, combined with the ease with which this nematode can be manipulated in the laboratory make it an attractive candidate to fulfill the role of an early stage in vivo model. Measuring the lifespan of C. elegans cultured in the presence of a range of concentrations of a NEDF would be of both mechanistic and strategic value in identifying those NEDFs that warrant further testing.
AB - The agriculture and food industries have an opportunity to change the future of food production by providing foods containing non-essential dietary factors (NEDFs) that improve health beyond a freedom from disease. In order to accomplish this in a safe and tune-effective manner, however, each NEDF needs to be tested on a number of levels before it is incorporated into foods. In vitro assays are useful for discovering potential beneficial NEDFS, but in vivo studies are needed to both confirm positive effects and to detect negative effects. The genetic and metabolic similarities between humans and Caenorhabditis elegans, combined with the ease with which this nematode can be manipulated in the laboratory make it an attractive candidate to fulfill the role of an early stage in vivo model. Measuring the lifespan of C. elegans cultured in the presence of a range of concentrations of a NEDF would be of both mechanistic and strategic value in identifying those NEDFs that warrant further testing.
KW - Caenorhabditis elegans
KW - Health
KW - Lifespan
KW - Non-essential dietary factors
UR - http://www.scopus.com/inward/record.url?scp=34547107056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547107056&partnerID=8YFLogxK
U2 - 10.1002/jsfa.2912
DO - 10.1002/jsfa.2912
M3 - Article
AN - SCOPUS:34547107056
VL - 87
SP - 1802
EP - 1805
JO - Journal of the Science of Food and Agriculture
JF - Journal of the Science of Food and Agriculture
SN - 0022-5142
IS - 10
ER -