Non-epithelial ovarian tumours: A review of selected patterns that mimic epithelial tumours and other high-grade malignancies

Joseph T. Rabban, Anthony Karnezis, Charles J. Zaloudek

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Non-epithelial ovarian tumours exhibit a diverse array of growth patterns that can mimic epithelial ovarian cancers or other high-grade malignancies. This review highlights selected morphologic features that may assist in the differential diagnosis, as well as recent advances in immunohistochemistry. Steroidogenic factor-1 is a novel marker for sex cord-stromal differentiation and is useful in the diagnosis of granulosa cell tumour. SALL4 is a novel marker of primitive germ cell tumours and is useful in the diagnosis of yolk sac tumour. Distinction of primary versus metastatic origin of carcinoid tumour is important and gross and microscopic features are more accurate to this end than immunohistochemistry, except for the value of TTF-1 in pulmonary or cervical neuroendocrine tumours. Finally, unusual presentations of struma ovarii are also discussed, including proliferative struma, extra-ovarian struma, and carcinoma arising within struma ovarii.

Original languageEnglish (US)
Pages (from-to)153-164
Number of pages12
JournalDiagnostic Histopathology
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

Keywords

  • Carcinoid tumour
  • Granulosa cell tumour
  • Ovarian germ cell tumour
  • Ovarian sex cord-
  • Stromal tumour
  • Struma ovarii
  • Yolk sac tumour

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Fingerprint Dive into the research topics of 'Non-epithelial ovarian tumours: A review of selected patterns that mimic epithelial tumours and other high-grade malignancies'. Together they form a unique fingerprint.

Cite this