Non-epithelial ovarian tumours: A review of selected patterns that mimic epithelial tumours and other high-grade malignancies

Joseph T. Rabban, Anthony Karnezis, Charles J. Zaloudek

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Non-epithelial ovarian tumours exhibit a diverse array of growth patterns that can mimic epithelial ovarian cancers or other high-grade malignancies. This review highlights selected morphologic features that may assist in the differential diagnosis, as well as recent advances in immunohistochemistry. Steroidogenic factor-1 is a novel marker for sex cord-stromal differentiation and is useful in the diagnosis of granulosa cell tumour. SALL4 is a novel marker of primitive germ cell tumours and is useful in the diagnosis of yolk sac tumour. Distinction of primary versus metastatic origin of carcinoid tumour is important and gross and microscopic features are more accurate to this end than immunohistochemistry, except for the value of TTF-1 in pulmonary or cervical neuroendocrine tumours. Finally, unusual presentations of struma ovarii are also discussed, including proliferative struma, extra-ovarian struma, and carcinoma arising within struma ovarii.

Original languageEnglish (US)
Pages (from-to)153-164
Number of pages12
JournalDiagnostic Histopathology
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2011
Externally publishedYes

Fingerprint

Struma Ovarii
Goiter
Immunohistochemistry
Steroidogenic Factor 1
Granulosa Cell Tumor
Endodermal Sinus Tumor
Neuroendocrine Tumors
Germ Cell and Embryonal Neoplasms
Carcinoid Tumor
Neoplasms
Differential Diagnosis
Carcinoma
Lung
Growth

Keywords

  • Carcinoid tumour
  • Granulosa cell tumour
  • Ovarian germ cell tumour
  • Ovarian sex cord-
  • Stromal tumour
  • Struma ovarii
  • Yolk sac tumour

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Non-epithelial ovarian tumours : A review of selected patterns that mimic epithelial tumours and other high-grade malignancies. / Rabban, Joseph T.; Karnezis, Anthony; Zaloudek, Charles J.

In: Diagnostic Histopathology, Vol. 17, No. 4, 01.04.2011, p. 153-164.

Research output: Contribution to journalArticle

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