Non-dehalogenation mechanisms for excretion of radioiodine after administration of labeled antibodies.

Gerald L Denardo, S. J. De Nardo, N. P. Miyao, S. L. Mills, J. S. Peng, L. F. O'Grady, A. L. Epstein, W. C. Young

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

In patients or mice with cancer the pharmacokinetic behavior of radioiodinated and radiometal chelated antibodies has been observed to be different. Rapid clearance from the tissues and excretion into the urine can occur after injection of radioiodinated antibodies. These observations have been interpreted to reflect in vivo dehalogenation of the antibody. This publication describes a variety of other mechanisms that can underlie these phenomena. These mechanisms include receptor uptake and catabolism of antibody and instability of the labeled antibody due to the labeling conditions. Specifically, the relative masses of chloramine-T and antibody in the iodination reaction mixture, the level of iodination of the antibody, and the amount of antibody administered to the recipient are all factors which can influence the clearance of radioiodinated antibody from the recipient. The final determinant for the different behavior of radioiodinated and In-111 metal chelated antibody relate to the different biologic pathways of indium when compared to iodine.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalInternational Journal of Biological Markers
Volume3
Issue number1
StatePublished - Jan 1988

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

Fingerprint Dive into the research topics of 'Non-dehalogenation mechanisms for excretion of radioiodine after administration of labeled antibodies.'. Together they form a unique fingerprint.

  • Cite this

    Denardo, G. L., De Nardo, S. J., Miyao, N. P., Mills, S. L., Peng, J. S., O'Grady, L. F., Epstein, A. L., & Young, W. C. (1988). Non-dehalogenation mechanisms for excretion of radioiodine after administration of labeled antibodies. International Journal of Biological Markers, 3(1), 1-9.