Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study

Tony Charman, Gregory S. Young, Jessica Brian, Alice Carter, Leslie J. Carver, Katarzyna Chawarska, Suzanne Curtin, Karen Dobkins, Mayada Elsabbagh, Stelios Georgiades, Irva Hertz-Picciotto, Ted Hutman, Jana M. Iverson, Emily J. Jones, Rebecca Landa, Suzanne Macari, Daniel S. Messinger, Charles A. Nelson, Sally J Ozonoff, Celine SaulnierWendy L. Stone, Helen Tager-Flusberg, Sara Jane Webb, Nurit Yirmiya, Lonnie Zwaigenbaum

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Lay Abstract: This study characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n=859), and low-risk controls with no family history of ASD (n=473). We characterized outcomes at age 3 years using a developmental assessment of language and learning and an observational measure of ASD symptoms and, where available, parent interviews about ASD behaviors and adaptive functioning. Around one-in-ten high-risk siblings had mild-to-moderate levels of developmental delay, a rate significantly higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. High-risk siblings were also more likely to have higher levels of observer-rated and parent-reported levels of ASD symptoms and lower adaptive functioning. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. We discuss these findings as evidence for early emerging characteristics related to the "broader autism phenotype" previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not show clear signs of ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes.

Original languageEnglish (US)
JournalAutism Research
DOIs
StateAccepted/In press - 2016

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Siblings
Research
Psychological Adaptation
Language Development Disorders
Autism Spectrum Disorder
Aptitude
Autistic Disorder
Language
Mothers
Learning
Interviews
Phenotype
Education

Keywords

  • Adaptive functioning
  • Autism spectrum disorder
  • Broader autism phenotype
  • Developmental outcomes
  • High risk siblings

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Genetics(clinical)

Cite this

Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD) : A baby siblings research consortium (BSRC) study. / Charman, Tony; Young, Gregory S.; Brian, Jessica; Carter, Alice; Carver, Leslie J.; Chawarska, Katarzyna; Curtin, Suzanne; Dobkins, Karen; Elsabbagh, Mayada; Georgiades, Stelios; Hertz-Picciotto, Irva; Hutman, Ted; Iverson, Jana M.; Jones, Emily J.; Landa, Rebecca; Macari, Suzanne; Messinger, Daniel S.; Nelson, Charles A.; Ozonoff, Sally J; Saulnier, Celine; Stone, Wendy L.; Tager-Flusberg, Helen; Webb, Sara Jane; Yirmiya, Nurit; Zwaigenbaum, Lonnie.

In: Autism Research, 2016.

Research output: Contribution to journalArticle

Charman, T, Young, GS, Brian, J, Carter, A, Carver, LJ, Chawarska, K, Curtin, S, Dobkins, K, Elsabbagh, M, Georgiades, S, Hertz-Picciotto, I, Hutman, T, Iverson, JM, Jones, EJ, Landa, R, Macari, S, Messinger, DS, Nelson, CA, Ozonoff, SJ, Saulnier, C, Stone, WL, Tager-Flusberg, H, Webb, SJ, Yirmiya, N & Zwaigenbaum, L 2016, 'Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study', Autism Research. https://doi.org/10.1002/aur.1669
Charman, Tony ; Young, Gregory S. ; Brian, Jessica ; Carter, Alice ; Carver, Leslie J. ; Chawarska, Katarzyna ; Curtin, Suzanne ; Dobkins, Karen ; Elsabbagh, Mayada ; Georgiades, Stelios ; Hertz-Picciotto, Irva ; Hutman, Ted ; Iverson, Jana M. ; Jones, Emily J. ; Landa, Rebecca ; Macari, Suzanne ; Messinger, Daniel S. ; Nelson, Charles A. ; Ozonoff, Sally J ; Saulnier, Celine ; Stone, Wendy L. ; Tager-Flusberg, Helen ; Webb, Sara Jane ; Yirmiya, Nurit ; Zwaigenbaum, Lonnie. / Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD) : A baby siblings research consortium (BSRC) study. In: Autism Research. 2016.
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abstract = "Lay Abstract: This study characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n=859), and low-risk controls with no family history of ASD (n=473). We characterized outcomes at age 3 years using a developmental assessment of language and learning and an observational measure of ASD symptoms and, where available, parent interviews about ASD behaviors and adaptive functioning. Around one-in-ten high-risk siblings had mild-to-moderate levels of developmental delay, a rate significantly higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. High-risk siblings were also more likely to have higher levels of observer-rated and parent-reported levels of ASD symptoms and lower adaptive functioning. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. We discuss these findings as evidence for early emerging characteristics related to the {"}broader autism phenotype{"} previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not show clear signs of ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes.",
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T1 - Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD)

T2 - A baby siblings research consortium (BSRC) study

AU - Charman, Tony

AU - Young, Gregory S.

AU - Brian, Jessica

AU - Carter, Alice

AU - Carver, Leslie J.

AU - Chawarska, Katarzyna

AU - Curtin, Suzanne

AU - Dobkins, Karen

AU - Elsabbagh, Mayada

AU - Georgiades, Stelios

AU - Hertz-Picciotto, Irva

AU - Hutman, Ted

AU - Iverson, Jana M.

AU - Jones, Emily J.

AU - Landa, Rebecca

AU - Macari, Suzanne

AU - Messinger, Daniel S.

AU - Nelson, Charles A.

AU - Ozonoff, Sally J

AU - Saulnier, Celine

AU - Stone, Wendy L.

AU - Tager-Flusberg, Helen

AU - Webb, Sara Jane

AU - Yirmiya, Nurit

AU - Zwaigenbaum, Lonnie

PY - 2016

Y1 - 2016

N2 - Lay Abstract: This study characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n=859), and low-risk controls with no family history of ASD (n=473). We characterized outcomes at age 3 years using a developmental assessment of language and learning and an observational measure of ASD symptoms and, where available, parent interviews about ASD behaviors and adaptive functioning. Around one-in-ten high-risk siblings had mild-to-moderate levels of developmental delay, a rate significantly higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. High-risk siblings were also more likely to have higher levels of observer-rated and parent-reported levels of ASD symptoms and lower adaptive functioning. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. We discuss these findings as evidence for early emerging characteristics related to the "broader autism phenotype" previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not show clear signs of ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes.

AB - Lay Abstract: This study characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n=859), and low-risk controls with no family history of ASD (n=473). We characterized outcomes at age 3 years using a developmental assessment of language and learning and an observational measure of ASD symptoms and, where available, parent interviews about ASD behaviors and adaptive functioning. Around one-in-ten high-risk siblings had mild-to-moderate levels of developmental delay, a rate significantly higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. High-risk siblings were also more likely to have higher levels of observer-rated and parent-reported levels of ASD symptoms and lower adaptive functioning. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. We discuss these findings as evidence for early emerging characteristics related to the "broader autism phenotype" previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not show clear signs of ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes.

KW - Adaptive functioning

KW - Autism spectrum disorder

KW - Broader autism phenotype

KW - Developmental outcomes

KW - High risk siblings

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