Abstract
Lay Abstract: This study characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n=859), and low-risk controls with no family history of ASD (n=473). We characterized outcomes at age 3 years using a developmental assessment of language and learning and an observational measure of ASD symptoms and, where available, parent interviews about ASD behaviors and adaptive functioning. Around one-in-ten high-risk siblings had mild-to-moderate levels of developmental delay, a rate significantly higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. High-risk siblings were also more likely to have higher levels of observer-rated and parent-reported levels of ASD symptoms and lower adaptive functioning. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. We discuss these findings as evidence for early emerging characteristics related to the "broader autism phenotype" previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not show clear signs of ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes.
| Original language | English (US) |
|---|---|
| Journal | Autism Research |
| DOIs | |
| State | Accepted/In press - 2016 |
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Keywords
- Adaptive functioning
- Autism spectrum disorder
- Broader autism phenotype
- Developmental outcomes
- High risk siblings
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Genetics(clinical)
Cite this
Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD) : A baby siblings research consortium (BSRC) study. / Charman, Tony; Young, Gregory S.; Brian, Jessica; Carter, Alice; Carver, Leslie J.; Chawarska, Katarzyna; Curtin, Suzanne; Dobkins, Karen; Elsabbagh, Mayada; Georgiades, Stelios; Hertz-Picciotto, Irva; Hutman, Ted; Iverson, Jana M.; Jones, Emily J.; Landa, Rebecca; Macari, Suzanne; Messinger, Daniel S.; Nelson, Charles A.; Ozonoff, Sally J; Saulnier, Celine; Stone, Wendy L.; Tager-Flusberg, Helen; Webb, Sara Jane; Yirmiya, Nurit; Zwaigenbaum, Lonnie.
In: Autism Research, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD)
T2 - A baby siblings research consortium (BSRC) study
AU - Charman, Tony
AU - Young, Gregory S.
AU - Brian, Jessica
AU - Carter, Alice
AU - Carver, Leslie J.
AU - Chawarska, Katarzyna
AU - Curtin, Suzanne
AU - Dobkins, Karen
AU - Elsabbagh, Mayada
AU - Georgiades, Stelios
AU - Hertz-Picciotto, Irva
AU - Hutman, Ted
AU - Iverson, Jana M.
AU - Jones, Emily J.
AU - Landa, Rebecca
AU - Macari, Suzanne
AU - Messinger, Daniel S.
AU - Nelson, Charles A.
AU - Ozonoff, Sally J
AU - Saulnier, Celine
AU - Stone, Wendy L.
AU - Tager-Flusberg, Helen
AU - Webb, Sara Jane
AU - Yirmiya, Nurit
AU - Zwaigenbaum, Lonnie
PY - 2016
Y1 - 2016
N2 - Lay Abstract: This study characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n=859), and low-risk controls with no family history of ASD (n=473). We characterized outcomes at age 3 years using a developmental assessment of language and learning and an observational measure of ASD symptoms and, where available, parent interviews about ASD behaviors and adaptive functioning. Around one-in-ten high-risk siblings had mild-to-moderate levels of developmental delay, a rate significantly higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. High-risk siblings were also more likely to have higher levels of observer-rated and parent-reported levels of ASD symptoms and lower adaptive functioning. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. We discuss these findings as evidence for early emerging characteristics related to the "broader autism phenotype" previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not show clear signs of ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes.
AB - Lay Abstract: This study characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n=859), and low-risk controls with no family history of ASD (n=473). We characterized outcomes at age 3 years using a developmental assessment of language and learning and an observational measure of ASD symptoms and, where available, parent interviews about ASD behaviors and adaptive functioning. Around one-in-ten high-risk siblings had mild-to-moderate levels of developmental delay, a rate significantly higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. High-risk siblings were also more likely to have higher levels of observer-rated and parent-reported levels of ASD symptoms and lower adaptive functioning. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. We discuss these findings as evidence for early emerging characteristics related to the "broader autism phenotype" previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not show clear signs of ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes.
KW - Adaptive functioning
KW - Autism spectrum disorder
KW - Broader autism phenotype
KW - Developmental outcomes
KW - High risk siblings
UR - http://www.scopus.com/inward/record.url?scp=84994079470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84994079470&partnerID=8YFLogxK
U2 - 10.1002/aur.1669
DO - 10.1002/aur.1669
M3 - Article
C2 - 27417857
AN - SCOPUS:84994079470
JO - Autism Research
JF - Autism Research
SN - 1939-3806
ER -