Noise power properties of a cone-beam CT system for breast cancer detection

Kai Yang, Alexander L C Kwan, Shih Ying Huang, Nathan J. Packard, John M Boone

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

The noise power properties of a cone-beam computed tomography (CT) system dedicated for breast cancer detection were investigated. Uniform polyethylene cylinders of various diameters were scanned under different system acquisition conditions. Noise power spectra were calculated from difference data generated by subtraction between two identical scans. Multidimensional noise power spectra (NPS) were used as the metric to evaluate the noise properties of the breast CT (bCT) under different system acquisition and reconstruction conditions. A comprehensive investigation of the noise properties was performed in regard to system acquisition parameters including kVp, mA, number of cone-beam projection images used, cone angle, and object size. The influence on reconstruction parameters including interpolation method, reconstruction filter, field of view, matrix size, and slice thickness were also studied. Under certain conditions, the zero-dimensional NPS (image variance) was used as a quantitative index to compare the influence from different scan parameters, especially the radiation dose. If the total scan dose is changed by linearly changing the total number of projection images while the dose per frame is kept constant, the noise power has a linear relationship with the reciprocal of the total dose. If the total scan dose is changed by linearly changing the dose per frame while the total number of projection images is kept constant, the noise power has a quadratic relationship with the reciprocal of the total dose. With the same amount of total dose, using fewer projection images results in lower image noise power in the CT image. Quantitative results from this noise power analysis provide guidance for the bCT system operation, optimization, and data reconstruction.

Original languageEnglish (US)
Pages (from-to)5317-5327
Number of pages11
JournalMedical Physics
Volume35
Issue number12
DOIs
StatePublished - 2008

Keywords

  • Breast cancer
  • Computed tomography (CT)
  • Cone-beam
  • Image quality
  • Noise power spectrum (NPS)

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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