NOD1 and NOD2: New functions linking endoplasmic reticulum stress and inflammation

Mariana X. Byndloss, Arina Marijke Keestra-Gounder, Andreas J Baumler, Renee M Tsolis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although viruses have long been known to subvert the endoplasmic reticulum (ER) for their replication, recent work has shown that this strategy is also used by bacterial pathogens and parasites to promote their intracellular growth. The ensuing disruption of cellular processes triggers a condition known as ER stress, which activates the host cell's unfolded protein response (UPR) to restore homeostasis. Recent work has linked the UPR, in particular the arm of this response that depends on the ER-resident sensor IRE1, to innate immunity and inflammation. Surprisingly, two intracellular innate immune receptors, NOD1 and NOD2, previously shown to sense bacterial peptidoglycan, were found to transduce ER stress signals to elicit inflammation. Given the known roles of both ER stress and NOD2 in chronic inflammatory diseases, including inflammatory bowel disease and type 2 diabetes, this new link has important implications for understanding the basis for these pathologies.

Original languageEnglish (US)
Pages (from-to)311-313
Number of pages3
JournalDNA and Cell Biology
Volume35
Issue number7
DOIs
StatePublished - Jul 1 2016

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Endoplasmic Reticulum Stress
Unfolded Protein Response
Inflammation
Endoplasmic Reticulum
Peptidoglycan
Innate Immunity
Type 2 Diabetes Mellitus
Parasites
Homeostasis
Chronic Disease
Pathology
Viruses
Growth

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

NOD1 and NOD2 : New functions linking endoplasmic reticulum stress and inflammation. / Byndloss, Mariana X.; Keestra-Gounder, Arina Marijke; Baumler, Andreas J; Tsolis, Renee M.

In: DNA and Cell Biology, Vol. 35, No. 7, 01.07.2016, p. 311-313.

Research output: Contribution to journalArticle

Byndloss, Mariana X. ; Keestra-Gounder, Arina Marijke ; Baumler, Andreas J ; Tsolis, Renee M. / NOD1 and NOD2 : New functions linking endoplasmic reticulum stress and inflammation. In: DNA and Cell Biology. 2016 ; Vol. 35, No. 7. pp. 311-313.
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