No effect of concanavalin A on the corneal graft reaction

Mark J Mannis, J. H. Krachmer

Research output: Contribution to journalArticlepeer-review


Penetrating corneal homografts were performed in albino rabbits. The experimental group received grafts soaked in a solution of concanavalin A; the control group received grafts soaked in lactated Ringer's solution. Animals with technically successful grafts were subsequently exposed to an additional antigenic stimulus from the corneal donor via skin grafting. This procedure produces a uniformly high rate of corneal graft rejection. The two groups were compared for the frequency and onset of the graft reaction to evaluate any effectiveness of concanavalin A in altering the graft reaction. Results demonstrated no differences between control and experimental groups. The significance of these findings is discussed.

Original languageEnglish (US)
Pages (from-to)382-386
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - 1981

ASJC Scopus subject areas

  • Ophthalmology


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