No effect of concanavalin A on the corneal graft reaction

Mark J Mannis, J. H. Krachmer

Research output: Contribution to journalArticle

Abstract

Penetrating corneal homografts were performed in albino rabbits. The experimental group received grafts soaked in a solution of concanavalin A; the control group received grafts soaked in lactated Ringer's solution. Animals with technically successful grafts were subsequently exposed to an additional antigenic stimulus from the corneal donor via skin grafting. This procedure produces a uniformly high rate of corneal graft rejection. The two groups were compared for the frequency and onset of the graft reaction to evaluate any effectiveness of concanavalin A in altering the graft reaction. Results demonstrated no differences between control and experimental groups. The significance of these findings is discussed.

Original languageEnglish (US)
Pages (from-to)382-386
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume20
Issue number3
StatePublished - 1981

Fingerprint

Concanavalin A
Transplants
Control Groups
Skin Transplantation
Graft Rejection
Allografts
Rabbits

ASJC Scopus subject areas

  • Ophthalmology

Cite this

No effect of concanavalin A on the corneal graft reaction. / Mannis, Mark J; Krachmer, J. H.

In: Investigative Ophthalmology and Visual Science, Vol. 20, No. 3, 1981, p. 382-386.

Research output: Contribution to journalArticle

@article{fd893269b5d04f6aaa59080419e2cceb,
title = "No effect of concanavalin A on the corneal graft reaction",
abstract = "Penetrating corneal homografts were performed in albino rabbits. The experimental group received grafts soaked in a solution of concanavalin A; the control group received grafts soaked in lactated Ringer's solution. Animals with technically successful grafts were subsequently exposed to an additional antigenic stimulus from the corneal donor via skin grafting. This procedure produces a uniformly high rate of corneal graft rejection. The two groups were compared for the frequency and onset of the graft reaction to evaluate any effectiveness of concanavalin A in altering the graft reaction. Results demonstrated no differences between control and experimental groups. The significance of these findings is discussed.",
author = "Mannis, {Mark J} and Krachmer, {J. H.}",
year = "1981",
language = "English (US)",
volume = "20",
pages = "382--386",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "3",

}

TY - JOUR

T1 - No effect of concanavalin A on the corneal graft reaction

AU - Mannis, Mark J

AU - Krachmer, J. H.

PY - 1981

Y1 - 1981

N2 - Penetrating corneal homografts were performed in albino rabbits. The experimental group received grafts soaked in a solution of concanavalin A; the control group received grafts soaked in lactated Ringer's solution. Animals with technically successful grafts were subsequently exposed to an additional antigenic stimulus from the corneal donor via skin grafting. This procedure produces a uniformly high rate of corneal graft rejection. The two groups were compared for the frequency and onset of the graft reaction to evaluate any effectiveness of concanavalin A in altering the graft reaction. Results demonstrated no differences between control and experimental groups. The significance of these findings is discussed.

AB - Penetrating corneal homografts were performed in albino rabbits. The experimental group received grafts soaked in a solution of concanavalin A; the control group received grafts soaked in lactated Ringer's solution. Animals with technically successful grafts were subsequently exposed to an additional antigenic stimulus from the corneal donor via skin grafting. This procedure produces a uniformly high rate of corneal graft rejection. The two groups were compared for the frequency and onset of the graft reaction to evaluate any effectiveness of concanavalin A in altering the graft reaction. Results demonstrated no differences between control and experimental groups. The significance of these findings is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0019495324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019495324&partnerID=8YFLogxK

M3 - Article

C2 - 7009484

AN - SCOPUS:0019495324

VL - 20

SP - 382

EP - 386

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 3

ER -