Abstract
Penetrating corneal homografts were performed in albino rabbits. The experimental group received grafts soaked in a solution of concanavalin A; the control group received grafts soaked in lactated Ringer's solution. Animals with technically successful grafts were subsequently exposed to an additional antigenic stimulus from the corneal donor via skin grafting. This procedure produces a uniformly high rate of corneal graft rejection. The two groups were compared for the frequency and onset of the graft reaction to evaluate any effectiveness of concanavalin A in altering the graft reaction. Results demonstrated no differences between control and experimental groups. The significance of these findings is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 382-386 |
| Number of pages | 5 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 20 |
| Issue number | 3 |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Ophthalmology
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No effect of concanavalin A on the corneal graft reaction. / Mannis, Mark J; Krachmer, J. H.
In: Investigative Ophthalmology and Visual Science, Vol. 20, No. 3, 1981, p. 382-386.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - No effect of concanavalin A on the corneal graft reaction
AU - Mannis, Mark J
AU - Krachmer, J. H.
PY - 1981
Y1 - 1981
N2 - Penetrating corneal homografts were performed in albino rabbits. The experimental group received grafts soaked in a solution of concanavalin A; the control group received grafts soaked in lactated Ringer's solution. Animals with technically successful grafts were subsequently exposed to an additional antigenic stimulus from the corneal donor via skin grafting. This procedure produces a uniformly high rate of corneal graft rejection. The two groups were compared for the frequency and onset of the graft reaction to evaluate any effectiveness of concanavalin A in altering the graft reaction. Results demonstrated no differences between control and experimental groups. The significance of these findings is discussed.
AB - Penetrating corneal homografts were performed in albino rabbits. The experimental group received grafts soaked in a solution of concanavalin A; the control group received grafts soaked in lactated Ringer's solution. Animals with technically successful grafts were subsequently exposed to an additional antigenic stimulus from the corneal donor via skin grafting. This procedure produces a uniformly high rate of corneal graft rejection. The two groups were compared for the frequency and onset of the graft reaction to evaluate any effectiveness of concanavalin A in altering the graft reaction. Results demonstrated no differences between control and experimental groups. The significance of these findings is discussed.
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M3 - Article
C2 - 7009484
AN - SCOPUS:0019495324
VL - 20
SP - 382
EP - 386
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 3
ER -