N,N-bond-forming heterocyclization: Synthesis of 3-alkoxy-2H-indazoles

Aaron D. Mills, Musa Z. Nazer, Makhluf J. Haddadin, Mark J. Kurth

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

A one-step heterocyclization of o-nitrobenzylamines to 3-alkoxy-2H- indazoles is reported. The electronic nature of the nitrophenyl group, the steric and electronic nature of the R1-functionalized benzylic amine, and the nature of the alcoholic solvent affect the efficiency of this heterocyclization reaction (∼40-90%).

Original languageEnglish (US)
Pages (from-to)2687-2689
Number of pages3
JournalJournal of Organic Chemistry
Volume71
Issue number7
DOIs
StatePublished - Apr 1 2006

ASJC Scopus subject areas

  • Organic Chemistry

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    Mills, A. D., Nazer, M. Z., Haddadin, M. J., & Kurth, M. J. (2006). N,N-bond-forming heterocyclization: Synthesis of 3-alkoxy-2H-indazoles. Journal of Organic Chemistry, 71(7), 2687-2689. https://doi.org/10.1021/jo0524831