Abstract
The pH dependent lactonization of trisialic acid was examined using NMR and CE techniques. The combined studies indicate that lactonization is a dynamic, pH dependent process that occurs with preferential lactonization between the carbonyl of the central residue and the reducing end C-9 hydroxyl group.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2250-2253 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 52 |
| Issue number | 17 |
| DOIs | |
| State | Published - Apr 27 2011 |
Fingerprint
Keywords
- Capillary electrophoresis
- Lactonization
- Nuclear magnetic resonance
- Regioselectivity
- Sialic acid
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
NMR studies of the reversible and regioselective lactonization of α-2,8-linked trisialic acid in aqueous acid. / Eckert, Timothy; Lu, Chun Ping; Chen, Chien Sheng; Wu, Shih Hsiung; Gervay-Hague, Jacquelyn.
In: Tetrahedron Letters, Vol. 52, No. 17, 27.04.2011, p. 2250-2253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - NMR studies of the reversible and regioselective lactonization of α-2,8-linked trisialic acid in aqueous acid
AU - Eckert, Timothy
AU - Lu, Chun Ping
AU - Chen, Chien Sheng
AU - Wu, Shih Hsiung
AU - Gervay-Hague, Jacquelyn
PY - 2011/4/27
Y1 - 2011/4/27
N2 - The pH dependent lactonization of trisialic acid was examined using NMR and CE techniques. The combined studies indicate that lactonization is a dynamic, pH dependent process that occurs with preferential lactonization between the carbonyl of the central residue and the reducing end C-9 hydroxyl group.
AB - The pH dependent lactonization of trisialic acid was examined using NMR and CE techniques. The combined studies indicate that lactonization is a dynamic, pH dependent process that occurs with preferential lactonization between the carbonyl of the central residue and the reducing end C-9 hydroxyl group.
KW - Capillary electrophoresis
KW - Lactonization
KW - Nuclear magnetic resonance
KW - Regioselectivity
KW - Sialic acid
UR - http://www.scopus.com/inward/record.url?scp=79953187213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953187213&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2011.01.019
DO - 10.1016/j.tetlet.2011.01.019
M3 - Article
AN - SCOPUS:79953187213
VL - 52
SP - 2250
EP - 2253
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 17
ER -