Abstract
The pH dependent lactonization of trisialic acid was examined using NMR and CE techniques. The combined studies indicate that lactonization is a dynamic, pH dependent process that occurs with preferential lactonization between the carbonyl of the central residue and the reducing end C-9 hydroxyl group.
Original language | English (US) |
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Pages (from-to) | 2250-2253 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 52 |
Issue number | 17 |
DOIs | |
State | Published - Apr 27 2011 |
Keywords
- Capillary electrophoresis
- Lactonization
- Nuclear magnetic resonance
- Regioselectivity
- Sialic acid
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery