Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis

Minjung J. Kim, Rajula Bhatia-Gaur, Whitney A. Banach-Petrosky, Nishita Desai, Michael M. Shen, Cory Abate-Shen, Minjung J. Kim, Rajula Bhatia-Gaur, Whitney A. Banach-Petrosky, Cory Abate-Shen, Cory Abate-Shen, Nishita Desai, Michael M. Shen, Michael M. Shen, Cory Abate-Shen, Yuzhuo Wang, Simon W. Hayward, Gerald R. Cunha, Robert Cardiff

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Abstract

Recent studies of human cancers and mutant mouse models have implicated the Nkx3.1 homeobox gene as having a key role in prostate carcinogenesis. Consistent with such a role, here we show that Nkx3.1 displays growth-suppressing activities in cell culture, and that aged Nkx3.1 mutant mice display histopathological defects resembling prostatic intraepithelial neoplasia (PIN), the presumed precursor of human prostate cancer. Using a tissue recombination approach, we found that PIN-like lesions from Nkx3.1 mutants can undergo progressively severe histopathological alterations after serial transplantation in nude mice. Our findings indicate that Nkx3.1 loss-of-function is a critical event in prostate cancer initiation, and that Nkx3.1 mutant mice accurately model early stages of prostate carcinogenesis. More generally, our tissue recombination assay provides an empirical test to examine the relationship of PIN to prostate carcinoma.

Original languageEnglish (US)
Pages (from-to)2999-3004
Number of pages6
JournalCancer Research
Volume62
Issue number11
StatePublished - Jun 1 2002

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kim, M. J., Bhatia-Gaur, R., Banach-Petrosky, W. A., Desai, N., Shen, M. M., Abate-Shen, C., Kim, M. J., Bhatia-Gaur, R., Banach-Petrosky, W. A., Abate-Shen, C., Abate-Shen, C., Desai, N., Shen, M. M., Shen, M. M., Abate-Shen, C., Wang, Y., Hayward, S. W., Cunha, G. R., & Cardiff, R. (2002). Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Research, 62(11), 2999-3004.