NK cells lacking FcεRIγ are associated with reduced liver damage in chronic hepatitis C virus infection

Jun S. Oh, Alaa K. Ali, Sung Jin Kim, Daniel J. Corsi, Curtis L. Cooper, Seung Hwan Lee

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A novel subset of human natural killer (NK) cells, which displays potent and broad antiviral responsiveness in concert with virus-specific antibodies, was recently uncovered in cytomegalovirus (CMV)+ individuals. This NK-cell subset (g-NK) was characterized by a deficiency in the expression of FcεRIγ adaptor protein and the long-lasting memory-like NK-cell phenotype, suggesting a role in chronic infections. This study investigates whether the g-NK-cell subset is associated with the magnitude of liver disease during chronic hepatitis C virus (HCV) infection. Analysis of g-NK-cell proportions and function in the PBMCs of healthy controls and chronic HCV subjects showed that chronic HCV subjects had slightly lower proportions of the g-NK-cell subset having similarly enhanced antibody-dependent cellular cytotoxicity responses compared to conventional NK cells. Notably, among CMV+ chronic HCV patients, lower levels of liver enzymes and fibrosis were found in those possessing g-NK cells. g-NK cells were predominant among the CD56neg NK cell population often found in chronic HCV patients, suggesting their involvement in immune response during HCV infection. For the first time, our findings indicate that the presence of the g-NK cells in CMV+ individuals is associated with amelioration of liver disease in chronic HCV infection, suggesting the beneficial roles of g-NK cells during a chronic infection.

Original languageEnglish (US)
Pages (from-to)1020-1029
Number of pages10
JournalEuropean Journal of Immunology
Volume46
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Keywords

  • ADCC Cytomegalovirus (CMV) Hepatitis C virus (HCV) Liver enzymes Liver fibrosis Natural killer (NK) cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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