Nitric oxide: A pro-inflammatory mediator in lung disease?

Albert Van Der Vliet, Jason P. Eiserich, Carroll E Cross

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO) and increased indices of NO-dependent oxidative stress. Although NO is known to have anti-microbial, anti-inflammatory and anti-oxidant properties, various lines of evidence support the contribution of NO to lung injury in several disease models. On the basis of biochemical evidence, it is often presumed that such NO-dependent oxidations are due to the formation of the oxidant peroxynitrite, although alternative mechanisms involving the phagocyte-derived heme proteins myeloperoxidase and eosinophil peroxidase might be operative during conditions of inflammation. Because of the overwhelming literature on NO generation and activities in the respiratory tract, it would be beyond the scope of this commentary to review this area comprehensively. Instead, it focuses on recent evidence and concepts of the presumed contribution of NO to inflammatory diseases of the lung.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalRespiratory Research
Volume1
Issue number2
DOIs
StatePublished - 2000

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Keywords

  • Inflammation
  • Neutrophil
  • Nitric oxide
  • Nitrotyrosine
  • Peroxidases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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