Nitric oxide: A pro-inflammatory mediator in lung disease?

Albert Van Der Vliet, Jason P. Eiserich, Carroll E Cross

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO) and increased indices of NO-dependent oxidative stress. Although NO is known to have anti-microbial, anti-inflammatory and anti-oxidant properties, various lines of evidence support the contribution of NO to lung injury in several disease models. On the basis of biochemical evidence, it is often presumed that such NO-dependent oxidations are due to the formation of the oxidant peroxynitrite, although alternative mechanisms involving the phagocyte-derived heme proteins myeloperoxidase and eosinophil peroxidase might be operative during conditions of inflammation. Because of the overwhelming literature on NO generation and activities in the respiratory tract, it would be beyond the scope of this commentary to review this area comprehensively. Instead, it focuses on recent evidence and concepts of the presumed contribution of NO to inflammatory diseases of the lung.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalRespiratory Research
Volume1
Issue number2
DOIs
StatePublished - 2000

Fingerprint

Lung Diseases
Nitric Oxide
Oxidants
Eosinophil Peroxidase
Hemeproteins
Respiratory Tract Diseases
Peroxynitrous Acid
Lung Injury
Phagocytes
Respiratory System
Peroxidase
Oxidative Stress
Anti-Inflammatory Agents
Inflammation

Keywords

  • Inflammation
  • Neutrophil
  • Nitric oxide
  • Nitrotyrosine
  • Peroxidases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Nitric oxide : A pro-inflammatory mediator in lung disease? / Van Der Vliet, Albert; Eiserich, Jason P.; Cross, Carroll E.

In: Respiratory Research, Vol. 1, No. 2, 2000, p. 67-72.

Research output: Contribution to journalArticle

Van Der Vliet, Albert ; Eiserich, Jason P. ; Cross, Carroll E. / Nitric oxide : A pro-inflammatory mediator in lung disease?. In: Respiratory Research. 2000 ; Vol. 1, No. 2. pp. 67-72.
@article{aeb204e53f984038a59cdb2659c09542,
title = "Nitric oxide: A pro-inflammatory mediator in lung disease?",
abstract = "Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO•) and increased indices of NO•-dependent oxidative stress. Although NO• is known to have anti-microbial, anti-inflammatory and anti-oxidant properties, various lines of evidence support the contribution of NO• to lung injury in several disease models. On the basis of biochemical evidence, it is often presumed that such NO•-dependent oxidations are due to the formation of the oxidant peroxynitrite, although alternative mechanisms involving the phagocyte-derived heme proteins myeloperoxidase and eosinophil peroxidase might be operative during conditions of inflammation. Because of the overwhelming literature on NO• generation and activities in the respiratory tract, it would be beyond the scope of this commentary to review this area comprehensively. Instead, it focuses on recent evidence and concepts of the presumed contribution of NO• to inflammatory diseases of the lung.",
keywords = "Inflammation, Neutrophil, Nitric oxide, Nitrotyrosine, Peroxidases",
author = "{Van Der Vliet}, Albert and Eiserich, {Jason P.} and Cross, {Carroll E}",
year = "2000",
doi = "10.1186/rr14",
language = "English (US)",
volume = "1",
pages = "67--72",
journal = "Respiratory Research",
issn = "1465-9921",
publisher = "BioMed Central",
number = "2",

}

TY - JOUR

T1 - Nitric oxide

T2 - A pro-inflammatory mediator in lung disease?

AU - Van Der Vliet, Albert

AU - Eiserich, Jason P.

AU - Cross, Carroll E

PY - 2000

Y1 - 2000

N2 - Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO•) and increased indices of NO•-dependent oxidative stress. Although NO• is known to have anti-microbial, anti-inflammatory and anti-oxidant properties, various lines of evidence support the contribution of NO• to lung injury in several disease models. On the basis of biochemical evidence, it is often presumed that such NO•-dependent oxidations are due to the formation of the oxidant peroxynitrite, although alternative mechanisms involving the phagocyte-derived heme proteins myeloperoxidase and eosinophil peroxidase might be operative during conditions of inflammation. Because of the overwhelming literature on NO• generation and activities in the respiratory tract, it would be beyond the scope of this commentary to review this area comprehensively. Instead, it focuses on recent evidence and concepts of the presumed contribution of NO• to inflammatory diseases of the lung.

AB - Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO•) and increased indices of NO•-dependent oxidative stress. Although NO• is known to have anti-microbial, anti-inflammatory and anti-oxidant properties, various lines of evidence support the contribution of NO• to lung injury in several disease models. On the basis of biochemical evidence, it is often presumed that such NO•-dependent oxidations are due to the formation of the oxidant peroxynitrite, although alternative mechanisms involving the phagocyte-derived heme proteins myeloperoxidase and eosinophil peroxidase might be operative during conditions of inflammation. Because of the overwhelming literature on NO• generation and activities in the respiratory tract, it would be beyond the scope of this commentary to review this area comprehensively. Instead, it focuses on recent evidence and concepts of the presumed contribution of NO• to inflammatory diseases of the lung.

KW - Inflammation

KW - Neutrophil

KW - Nitric oxide

KW - Nitrotyrosine

KW - Peroxidases

UR - http://www.scopus.com/inward/record.url?scp=0034581322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034581322&partnerID=8YFLogxK

U2 - 10.1186/rr14

DO - 10.1186/rr14

M3 - Article

C2 - 11667967

AN - SCOPUS:0034581322

VL - 1

SP - 67

EP - 72

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

IS - 2

ER -