Nitrate, nitrite and nitric oxide reductases: From the last universal common ancestor to modern bacterial pathogens

Andrés Vázquez-Torres, Andreas J Baumler

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The electrochemical gradient that ensues from the enzymatic activity of cytochromes such as nitrate reductase, nitric oxide reductase, and quinol oxidase contributes to the bioenergetics of the bacterial cell. Reduction of nitrogen oxides by bacterial pathogens can, however, be uncoupled from proton translocation and biosynthesis of ATP or NH4 +, but still linked to quinol and NADH oxidation. Ancestral nitric oxide reductases, as well as cytochrome c oxidases and quinol bo oxidases evolved from the former, are capable of binding and detoxifying nitric oxide to nitrous oxide. The NO-metabolizing activity associated with these cytochromes can be a sizable source of antinitrosative defense in bacteria during their associations with host cells. Nitrosylation of terminal cytochromes arrests respiration, reprograms bacterial metabolism, stimulates antioxidant defenses and alters antibiotic cytotoxicity. Collectively, the bioenergetics and regulation of redox homeostasis that accompanies the utilization of nitrogen oxides and detoxification of nitric oxide by cytochromes of the electron transport chain increases fitness of many Gram-positive and -negative pathogens during their associations with invertebrate and vertebrate hosts.

Original languageEnglish (US)
Article number1395
Pages (from-to)1-8
Number of pages8
JournalCurrent Opinion in Microbiology
Volume29
DOIs
StatePublished - Feb 1 2016

Fingerprint

Cytochromes
Nitrites
Nitrates
Nitrogen Oxides
Energy Metabolism
Nitric Oxide
Hydroquinones
Nitrate Reductase
Nitrous Oxide
Electron Transport Complex IV
Invertebrates
Electron Transport
NAD
Oxidation-Reduction
Vertebrates
Protons
Respiration
Homeostasis
Antioxidants
Adenosine Triphosphate

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

Cite this

Nitrate, nitrite and nitric oxide reductases : From the last universal common ancestor to modern bacterial pathogens. / Vázquez-Torres, Andrés; Baumler, Andreas J.

In: Current Opinion in Microbiology, Vol. 29, 1395, 01.02.2016, p. 1-8.

Research output: Contribution to journalArticle

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