TY - JOUR
T1 - Nighttime delivery and risk of neonatal encephalopathy
AU - Wu, Yvonne W.
AU - Pham, Trinh N.
AU - Danielsen, Beate
AU - Towner, Dena
AU - Smith, Lloyd H
AU - Johnston, S. Claiborne
PY - 2011/1
Y1 - 2011/1
N2 - OBJECTIVE: The objective of the study was to determine the relationship between nighttime delivery and neonatal encephalopathy (NE). STUDY DESIGN: The design of the study was a retrospective population-based cohort of 1,864,766 newborns at a gestation of 36 weeks or longer in California, 1999-2002. We determined the risk of NE associated with nighttime delivery (7:00 pm to 6:59 am). RESULTS: Two thousand one hundred thirty-one patients had NE (incidence 1.1 per 1000 births). Nighttime delivery was associated with increased NE (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.031.20), birth asphyxia (OR, 1.18; 95% CI, 1.081.29), and neonatal seizures (OR, 1.17; 95% CI, 1.071.28). In adjusted analyses, nighttime delivery was an independent risk factor for NE (OR, 1.10; 95% CI, 1.011.21), as were severe intrauterine growth retardation (OR, 3.8; 95% CI, 3.14.8); no prenatal care (OR, 2.0; 95% CI, 1.42.9); primiparity (OR, 1.5; 95% CI, 1.41.7); advanced maternal age (OR, 1.3; 95% CI, 1.161.45); and infant male sex (OR, 1.3; 95% CI, 1.21.4). CONCLUSION: Future studies of time of delivery may generate new strategies to reduce the burden of NE.
AB - OBJECTIVE: The objective of the study was to determine the relationship between nighttime delivery and neonatal encephalopathy (NE). STUDY DESIGN: The design of the study was a retrospective population-based cohort of 1,864,766 newborns at a gestation of 36 weeks or longer in California, 1999-2002. We determined the risk of NE associated with nighttime delivery (7:00 pm to 6:59 am). RESULTS: Two thousand one hundred thirty-one patients had NE (incidence 1.1 per 1000 births). Nighttime delivery was associated with increased NE (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.031.20), birth asphyxia (OR, 1.18; 95% CI, 1.081.29), and neonatal seizures (OR, 1.17; 95% CI, 1.071.28). In adjusted analyses, nighttime delivery was an independent risk factor for NE (OR, 1.10; 95% CI, 1.011.21), as were severe intrauterine growth retardation (OR, 3.8; 95% CI, 3.14.8); no prenatal care (OR, 2.0; 95% CI, 1.42.9); primiparity (OR, 1.5; 95% CI, 1.41.7); advanced maternal age (OR, 1.3; 95% CI, 1.161.45); and infant male sex (OR, 1.3; 95% CI, 1.21.4). CONCLUSION: Future studies of time of delivery may generate new strategies to reduce the burden of NE.
KW - birth asphyxia
KW - epidemiology
KW - neonatal encephalopathy
KW - time of birth
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UR - http://www.scopus.com/inward/citedby.url?scp=78650702247&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2010.09.022
DO - 10.1016/j.ajog.2010.09.022
M3 - Article
C2 - 21074140
AN - SCOPUS:78650702247
VL - 204
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 1
ER -