Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis

Andrey Frolov, Hua Dong, Min Jiang, Lihua Yang, Erik C. Cook, Rahul Matnani, Bruce D. Hammock, Leslie J. Crofford

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: NPC2 is a protein that negatively regulates fibroblast activation. Results: NPC2-null human fibroblasts display induction of cPLA2, COX-2, and mPGES-1 expression that may contribute to the observed robust and selective activation of PGE2 biosynthesis. Conclusion: NPC2 may regulate the activated fibroblast inflammatory program through modulation of a cPLA2-dependent biosynthetic pathway. Significance: NPC2 may represent a novel therapeutic tool for the treatment of inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)23696-23703
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Frolov, A., Dong, H., Jiang, M., Yang, L., Cook, E. C., Matnani, R., Hammock, B. D., & Crofford, L. J. (2013). Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis. Journal of Biological Chemistry, 288(33), 23696-23703. https://doi.org/10.1074/jbc.M112.445916