Nicotinic acetylcholine receptor: evidence for a functionally distinct receptor on human lymphocytes.

David P Richman, B. G. Arnason

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

The presence of three distinct cholinergic receptors on human lymphocytes was suggested by the effects of carbamoylcholine on lymphocyte proliferation in vitro. The cells responded to both 0.1 nM and 1 microM carbamoylcholine by increased proliferation which was blocked by the muscarinic antagonist atropine. This effect occurred in both mitogen-stimulated cells (maximum effect at 24 hr) and nonstimulated cells (maximum effect at 72 hr). In contrast, 1--10 nM carbamoylcholine produced diminished in vitro proliferation, an effect which was blocked by the nicotinic antagonists alpha-bungarotoxin and d-tubocurarine.

Original languageEnglish (US)
Pages (from-to)4632-4635
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number9
StatePublished - Sep 1979
Externally publishedYes

ASJC Scopus subject areas

  • General
  • Genetics

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