Abstract
We examined the relationship between nicotine-induced vasoconstriction in pregnant rat dams and fetal growth during the third trimester of pregnancy. Pregnant rats were continuously treated between days 13 and 19 of gestation with either nicotine (9.6, 4.8 or 2.4 mg/kg/day), epinephrine (0.72 μg/kg/day), or saline via continuous infusion from a subcutaneously implanted osmotic minipump. Placental weights in rats treated with high dose nicotine and dams' body weights were severely reduced. However, fetal weights were not affected. Blood flows in uterus and placenta were quantified by measurement of tissue content of 85Sr-labelled microspheres injected via a carotid artery catherer. Both nicotine and epinphrine caused a significant reduction (> 40%) in uterine and placental blood flow. We conclude that vasoconstriction alone as a result of nicotine or epinephrine administration during the last trimester of gestation does not necessarily reduce nutrient supply to the fetus and does not affect fetal growth in rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 69-80 |
| Number of pages | 12 |
| Journal | Toxicology |
| Volume | 94 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - 1994 |
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Keywords
- Blood flow
- Cigarette smoke
- Epinephrine
- Fetal growth
- Fetal nutrient supply
- Nicotine
- Osmotic minipump delivery
- Transplacental diffusion
ASJC Scopus subject areas
- Toxicology
Cite this
Nicotine- or epinephrine-induced uteroplacental vasoconstriction and fetal growth in the rat. / Birnbaum, Samuel C.; Nguyen Kien, Kien; Martucci, Richard W.; Gelzleichter, Thomas R.; Witschi, Hanspeter; Hendrickx, Andrew G; Last, Jerold A.
In: Toxicology, Vol. 94, No. 1-3, 1994, p. 69-80.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nicotine- or epinephrine-induced uteroplacental vasoconstriction and fetal growth in the rat
AU - Birnbaum, Samuel C.
AU - Nguyen Kien, Kien
AU - Martucci, Richard W.
AU - Gelzleichter, Thomas R.
AU - Witschi, Hanspeter
AU - Hendrickx, Andrew G
AU - Last, Jerold A
PY - 1994
Y1 - 1994
N2 - We examined the relationship between nicotine-induced vasoconstriction in pregnant rat dams and fetal growth during the third trimester of pregnancy. Pregnant rats were continuously treated between days 13 and 19 of gestation with either nicotine (9.6, 4.8 or 2.4 mg/kg/day), epinephrine (0.72 μg/kg/day), or saline via continuous infusion from a subcutaneously implanted osmotic minipump. Placental weights in rats treated with high dose nicotine and dams' body weights were severely reduced. However, fetal weights were not affected. Blood flows in uterus and placenta were quantified by measurement of tissue content of 85Sr-labelled microspheres injected via a carotid artery catherer. Both nicotine and epinphrine caused a significant reduction (> 40%) in uterine and placental blood flow. We conclude that vasoconstriction alone as a result of nicotine or epinephrine administration during the last trimester of gestation does not necessarily reduce nutrient supply to the fetus and does not affect fetal growth in rats.
AB - We examined the relationship between nicotine-induced vasoconstriction in pregnant rat dams and fetal growth during the third trimester of pregnancy. Pregnant rats were continuously treated between days 13 and 19 of gestation with either nicotine (9.6, 4.8 or 2.4 mg/kg/day), epinephrine (0.72 μg/kg/day), or saline via continuous infusion from a subcutaneously implanted osmotic minipump. Placental weights in rats treated with high dose nicotine and dams' body weights were severely reduced. However, fetal weights were not affected. Blood flows in uterus and placenta were quantified by measurement of tissue content of 85Sr-labelled microspheres injected via a carotid artery catherer. Both nicotine and epinphrine caused a significant reduction (> 40%) in uterine and placental blood flow. We conclude that vasoconstriction alone as a result of nicotine or epinephrine administration during the last trimester of gestation does not necessarily reduce nutrient supply to the fetus and does not affect fetal growth in rats.
KW - Blood flow
KW - Cigarette smoke
KW - Epinephrine
KW - Fetal growth
KW - Fetal nutrient supply
KW - Nicotine
KW - Osmotic minipump delivery
KW - Transplacental diffusion
UR - http://www.scopus.com/inward/record.url?scp=0027994739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027994739&partnerID=8YFLogxK
U2 - 10.1016/0300-483X(94)90029-9
DO - 10.1016/0300-483X(94)90029-9
M3 - Article
C2 - 7801331
AN - SCOPUS:0027994739
VL - 94
SP - 69
EP - 80
JO - Toxicology
JF - Toxicology
SN - 0300-483X
IS - 1-3
ER -