Nicotine exerts differential effects on different CA1 hippocampal cell types

Laura J. Reece, Philip A Schwartzkroin

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The effects of (-) nicotine hydrogen tartrate (NHT) were examined on several cell types in the CA1 region of rat hippocampus. The results indicate that nicotine may have a preferential net inhibitory effect on basket cells and an excitatory effect on oriens/alveus interneurons. The resultant effects of nicotine on pyramidal cells may thus be a product of complex local circuit interactions.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalBrain Research
Issue number1-2
StatePublished - Feb 1 1991
Externally publishedYes


  • Acetylcholine
  • CA1
  • Interneuron
  • Nicotine
  • Rat hippocampus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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