Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type

Elena Estrada, Sarah M. Hartz, Jeffrey Tran, Donald M. Hilty, Pamela Sklar, Jordan W. Smoller, Carlos N. Pato, Michele T. Pato

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Patients with Bipolar disorder smoke more than the general population. Smoking negatively impacts mortality and clinical course in Bipolar disorder patients. Prior studies have shown contradictory results regarding the impact of psychosis on smoking behavior in Bipolar disorder. We analyzed a large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent. Data from subjects and controls were collected from the Genomic Psychiatry Cohort (GPC). Subjects were diagnosed with Bipolar disorder without psychosis (N=610), Bipolar disorder with psychosis (N=1544). Participants were classified with or without nicotine dependence. Diagnostic groups were compared to controls (N=10065) using logistic regression. Among smokers (N=6157), those with Bipolar disorder had an increased risk of nicotine dependence (OR=2.5; P

Original languageEnglish (US)
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
StateAccepted/In press - 2015
Externally publishedYes


  • Cigarettes
  • Severe mental illness
  • Smoking

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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