Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes

Chiao Po Hsu, Nirmala Hariharan, Ralph R. Alcendor, Shinichi Oka, Junichi Sadoshima

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Nicotinamide adenine dinucleotide (NAD+) acts as a transfer molecule for electrons, thereby acting as a key cofactor for energy production. NAD+ also serves as a substrate for cellular enzymes, including poly (ADPribose) polymerase (PARP)-1 and Sirt1. Activation of PARP-1 by DNA damage depletes the cellular pool of NAD+, leading to necrotic cell death. NAD+ in the nucleus enhances the activity of Sirt1, thereby modulating transcription. NAD+ is either synthesized de novo from amino acids, namely tryptophan and aspartic acid, or resynthesized from NAD + metabolites, such as nicotinamide (NAM), through the salvage pathway. NAM phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the NAD+ salvage pathway. We have recently demonstrated that Nampt is an important regulator of NAD+ and autophagy in cardiomyocytes. Here we discuss the role of Nampt in regulating autophagy and potential mechanisms by which NAD+ regulates autophagy in the heart.

Original languageEnglish (US)
Pages (from-to)1229-1231
Number of pages3
JournalAutophagy
Volume5
Issue number8
DOIs
StatePublished - Nov 16 2009
Externally publishedYes

Fingerprint

Nicotinamide Phosphoribosyltransferase
Autophagy
Cardiac Myocytes
NAD
Cell Survival
Poly(ADP-ribose) Polymerases
Niacinamide
Enzymes
Aspartic Acid
Tryptophan
DNA Damage
Cell Death

Keywords

  • Autophagy
  • Ischemia
  • Longevity factor
  • Nampt
  • Sirt1

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. / Hsu, Chiao Po; Hariharan, Nirmala; Alcendor, Ralph R.; Oka, Shinichi; Sadoshima, Junichi.

In: Autophagy, Vol. 5, No. 8, 16.11.2009, p. 1229-1231.

Research output: Contribution to journalArticle

Hsu, Chiao Po ; Hariharan, Nirmala ; Alcendor, Ralph R. ; Oka, Shinichi ; Sadoshima, Junichi. / Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. In: Autophagy. 2009 ; Vol. 5, No. 8. pp. 1229-1231.
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