Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

Su Ju Lin, Leonard Guarente

Research output: Contribution to journalArticle

335 Scopus citations

Abstract

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions. Recent studies show that NAD also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. It has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family, which are NAD-dependent deacetylases. Many human diseases are associated with changes in NAD level and/or the NAD: NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume15
Issue number2
DOIs
StatePublished - Apr 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology

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