TY - JOUR
T1 - Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
AU - Lin, Su Ju
AU - Guarente, Leonard
PY - 2003/4
Y1 - 2003/4
N2 - Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions. Recent studies show that NAD also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. It has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family, which are NAD-dependent deacetylases. Many human diseases are associated with changes in NAD level and/or the NAD: NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases.
AB - Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions. Recent studies show that NAD also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. It has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family, which are NAD-dependent deacetylases. Many human diseases are associated with changes in NAD level and/or the NAD: NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases.
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U2 - 10.1016/S0955-0674(03)00006-1
DO - 10.1016/S0955-0674(03)00006-1
M3 - Article
C2 - 12648681
AN - SCOPUS:0037376665
VL - 15
SP - 241
EP - 246
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 2
ER -