Abstract
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions. Recent studies show that NAD also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. It has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family, which are NAD-dependent deacetylases. Many human diseases are associated with changes in NAD level and/or the NAD: NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 241-246 |
| Number of pages | 6 |
| Journal | Current Opinion in Cell Biology |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2003 |
| Externally published | Yes |
ASJC Scopus subject areas
- Cell Biology
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Cite this
Lin, S. J., & Guarente, L. (2003). Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Current Opinion in Cell Biology, 15(2), 241-246. https://doi.org/10.1016/S0955-0674(03)00006-1