NGF prevention of neurotoxicity induced by cisplatin, vincristine and taxol depends on toxicity of each drug and NGF treatment schedule: In vitro study of adult rat sympathetic ganglion explants

Kazuhiro Hayakawa, Takayuki Ito, Hisayoshi Niwa, Tatsuro Mutoh, Gen Sobue

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The simultaneous administration of nerve growth factor (NGF) has been found to prevent experimental neuropathies induced by anti-cancer drugs such as cisplatin, vincristine and taxol. However, it is clinically important to know whether NGF is beneficial once the neuropathy is already manifest. We established a bioassay system to examine the preventive effects of NGF in various treatment schedules. NGF significantly prevented the inhibition of neurite outgrowth by vincristine and taxol regardless of treatment schedules. The pre-treatment and co-treatment schedules were effective against cisplatin, but the post-treatment schedule was not. With regard to the neurite and nerve cell population densities, only the cisplatin group treated with NGF showed lower values than the control. These results indicate that NGF-treatment is effective for the toxic sympathetic nerve injury induced by vincristine and taxol regardless of the treatment schedule, but is not protective against cisplatin-induced nerve cell injury.

Original languageEnglish (US)
Pages (from-to)313-319
Number of pages7
JournalBrain Research
Volume794
Issue number2
DOIs
StatePublished - Jun 1 1998
Externally publishedYes

Fingerprint

Sympathetic Ganglia
Vincristine
Nerve Growth Factor
Paclitaxel
Drug-Related Side Effects and Adverse Reactions
Cisplatin
Appointments and Schedules
Neurons
Poisons
Wounds and Injuries
Neurites
Population Density
Biological Assay
In Vitro Techniques
Cell Count
Pharmaceutical Preparations
Neoplasms

Keywords

  • Cisplatin
  • Nerve growth factor
  • Rat
  • Superior cervical ganglia
  • Taxol
  • Vincristine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

NGF prevention of neurotoxicity induced by cisplatin, vincristine and taxol depends on toxicity of each drug and NGF treatment schedule : In vitro study of adult rat sympathetic ganglion explants. / Hayakawa, Kazuhiro; Ito, Takayuki; Niwa, Hisayoshi; Mutoh, Tatsuro; Sobue, Gen.

In: Brain Research, Vol. 794, No. 2, 01.06.1998, p. 313-319.

Research output: Contribution to journalArticle

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