NGF and its receptor system: A new dimension in the pathogenesis of psoriasis and psoriatic arthritis

Smriti K. Raychaudhuri, Siba P Raychaudhuri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

33 Scopus citations

Abstract

A contributing role of nerve growth factor (NGF)-mediated neuroimmunologic mechanisms has provided a new dimension in the understanding of various cutaneous and systemic inflammatory diseases. Recent evidence implicates NGF as a key mediator of inflammation and pain. NGF influences an inflammatory reaction by regulating neuropeptides, angiogenesis, cell trafficking molecules, and T cell activation. All of these functions of NGF are relevant in maintenance or initiation of the critical biologic events in various rheumatologic conditions. The recognition of a pathologic role of NGF and its receptor system has provided an attractive opportunity to develop a novel class of therapeutics for inflammatory diseases and chronic pain syndromes. In this chapter we will discuss the role of NGF and its receptor system in psoriatic disease, inflammatory arthritis, and arthritic pain of osteoarthritis.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages470-477
Number of pages8
Volume1173
DOIs
StatePublished - Sep 2009
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1173
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • NGF
  • Psoriasis
  • Psoriatic arthritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Raychaudhuri, S. K., & Raychaudhuri, S. P. (2009). NGF and its receptor system: A new dimension in the pathogenesis of psoriasis and psoriatic arthritis. In Annals of the New York Academy of Sciences (Vol. 1173, pp. 470-477). (Annals of the New York Academy of Sciences; Vol. 1173). https://doi.org/10.1111/j.1749-6632.2009.04652.x