NF-kappaB2/p52 in prostate cancer

Nagalakshmi Nadiminty, Ramakumar Tummala, Yezi Zhu, Allen C Gao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The NF-κB transcription factor family members play pivotal roles in several biological and molecular processes. Two pathways of activation of NF-κB family members exist: a classical pathway involving a sequence of events leading to nuclear translocation of p65:p50 heterodimers and a non-canonical pathway involving the partial signal-induced processing of NF-κB2/p100 and the nuclear translocation of p52-containing heterodimers. NF-κB proteins are involved in a variety of lymphoid and epithelial cancers as well as prostate cancer. In this chapter, the role of classical NF-κB is briefly described while the novel role of NF-κB2/p52 in prostate cancer is discussed in detail. Activated STAT3 mediates enhanced processing of p100 leading to higher levels of p52 in prostate cancer. NF-κB2/p52 is overexpressed in prostate cancer, interacts with the androgen receptor in prostate cancer, and enhances ligand-independent growth and survival of prostate cancer cells. In addition, p52 regulates a wide variety of target genes that are involved in metastasis and angiogenesis. Downregulation of endogenous p52 in prostate cancer cells inhibits prostate cancer growth. NF-κB2/p52 is strongly implicated in the progression of castration-resistant prostate cancer, suggesting that targeting this transcription factor may have beneficial effects in therapy of this disease.

Original languageEnglish (US)
Title of host publicationProstate Cancer
Subtitle of host publicationBiochemistry, Molecular Biology and Genetics
PublisherSpringer New York
Pages257-273
Number of pages17
ISBN (Electronic)9781461468288
ISBN (Print)9781461468271
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'NF-kappaB2/p52 in prostate cancer'. Together they form a unique fingerprint.

  • Cite this

    Nadiminty, N., Tummala, R., Zhu, Y., & Gao, A. C. (2013). NF-kappaB2/p52 in prostate cancer. In Prostate Cancer: Biochemistry, Molecular Biology and Genetics (pp. 257-273). Springer New York. https://doi.org/10.1007/978-1-4614-6828-8_9