NF-κB-mediated adaptive resistance to ionizing radiation

Kazi Mokim Ahmed, Jian-Jian Li

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Ionizing radiation (IR) began to be a powerful medical modality soon after Wilhelm Röntgen's discovery of X-rays in 1895. Today, more than 50% of cancer patients receive radiotherapy at some time during the course of their disease. Recent technical developments have significantly increased the precision of dose delivery to the target tumor, making radiotherapy more efficient in cancer treatment. However, tumor cells have been shown to acquire a radioresistance that has been linked to increased recurrence and failure in many patients. The exact mechanisms by which tumor cells develop an adaptive resistance to therapeutic fractional irradiation are unknown, although low-dose IR has been well defined for radioadaptive protection of normal cells. This review will address the radioadaptive response, emphasizing recent studies of molecular-level reactions. A prosurvival signaling network initiated by the transcription factor NF-κB, DNA-damage sensor ATM, oncoprotein HER-2, cell cyclin elements (cyclin B1), and mitochondrial functions in radioadaptive resistance is discussed. Further elucidation of the key elements in this prosurvival network may generate novel targets for resensitizing the radioresistant tumor cells.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalFree Radical Biology and Medicine
Volume44
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Ionizing radiation
Ionizing Radiation
Tumors
Cells
Radiotherapy
Dosimetry
Neoplasms
Cyclin B1
Cyclins
Oncology
Oncogene Proteins
Automatic teller machines
Transcription Factors
Cytoprotection
Irradiation
X rays
DNA Damage
DNA
Sensors
X-Rays

Keywords

  • Adaptive radiation resistance
  • Free radicals
  • Ionizing radiation
  • NF-κB
  • Signal transduction

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Clinical Biochemistry

Cite this

NF-κB-mediated adaptive resistance to ionizing radiation. / Mokim Ahmed, Kazi; Li, Jian-Jian.

In: Free Radical Biology and Medicine, Vol. 44, No. 1, 01.01.2008, p. 1-13.

Research output: Contribution to journalArticle

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