Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils

K. M. Lam, M. B. Kabbur, J. P. Eiserich

Research output: Contribution to journalArticle

25 Scopus citations


The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.

Original languageEnglish (US)
Pages (from-to)313-327
Number of pages15
JournalVeterinary Immunology and Immunopathology
Issue number3-4
StatePublished - Oct 1996



  • Chicken
  • Heterophils
  • Newcastle disease virus

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this