Abstract
The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 313-327 |
| Number of pages | 15 |
| Journal | Veterinary Immunology and Immunopathology |
| Volume | 53 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - Oct 1996 |
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Keywords
- Chicken
- Heterophils
- Newcastle disease virus
ASJC Scopus subject areas
- Animal Science and Zoology
- Immunology
- veterinary(all)
Cite this
Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils. / Lam, K. M.; Kabbur, M. B.; Eiserich, J. P.
In: Veterinary Immunology and Immunopathology, Vol. 53, No. 3-4, 10.1996, p. 313-327.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils
AU - Lam, K. M.
AU - Kabbur, M. B.
AU - Eiserich, J. P.
PY - 1996/10
Y1 - 1996/10
N2 - The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.
AB - The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.
KW - Chicken
KW - Heterophils
KW - Newcastle disease virus
UR - http://www.scopus.com/inward/record.url?scp=0030272579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030272579&partnerID=8YFLogxK
U2 - 10.1016/S0165-2427(96)05612-7
DO - 10.1016/S0165-2427(96)05612-7
M3 - Article
C2 - 8969051
AN - SCOPUS:0030272579
VL - 53
SP - 313
EP - 327
JO - Veterinary Immunology and Immunopathology
JF - Veterinary Immunology and Immunopathology
SN - 0165-2427
IS - 3-4
ER -