Abstract
The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.
Original language | English (US) |
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Pages (from-to) | 313-327 |
Number of pages | 15 |
Journal | Veterinary Immunology and Immunopathology |
Volume | 53 |
Issue number | 3-4 |
DOIs | |
State | Published - Oct 1996 |
Keywords
- Chicken
- Heterophils
- Newcastle disease virus
ASJC Scopus subject areas
- Animal Science and Zoology
- Immunology
- veterinary(all)