Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils

K. M. Lam, M. B. Kabbur, J. P. Eiserich

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.

Original languageEnglish (US)
Pages (from-to)313-327
Number of pages15
JournalVeterinary Immunology and Immunopathology
Volume53
Issue number3-4
DOIs
StatePublished - Oct 1996

Fingerprint

Newcastle disease virus
heterophils
Chickens
chickens
Bacteria
Virus Diseases
Flow Cytometry
Nitric Oxide
Nitrogen
Apoptosis
Oxygen
DNA
Infection
bacteria
infection
nitric oxide
flow cytometry
apoptosis
oxygen
nitrogen

Keywords

  • Chicken
  • Heterophils
  • Newcastle disease virus

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

Cite this

Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils. / Lam, K. M.; Kabbur, M. B.; Eiserich, J. P.

In: Veterinary Immunology and Immunopathology, Vol. 53, No. 3-4, 10.1996, p. 313-327.

Research output: Contribution to journalArticle

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