Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils

K. M. Lam; M. B. Kabbur; J. P. Eiserich

doi:10.1016/S0165-2427(96)05612-7

Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils

K. M. Lam, M. B. Kabbur, J. P. Eiserich

Nephrology

Research output: Contribution to journal › Article

25 Scopus citations

Abstract

The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H₂O₂ production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.

Original language	English (US)
Pages (from-to)	313-327
Number of pages	15
Journal	Veterinary Immunology and Immunopathology
Volume	53
Issue number	3-4
DOIs	https://doi.org/10.1016/S0165-2427(96)05612-7
State	Published - Oct 1996

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Keywords

Chicken
Heterophils
Newcastle disease virus

ASJC Scopus subject areas

Animal Science and Zoology
Immunology
veterinary(all)

Cite this

Lam, K. M., Kabbur, M. B., & Eiserich, J. P. (1996). Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils. Veterinary Immunology and Immunopathology, 53(3-4), 313-327. https://doi.org/10.1016/S0165-2427(96)05612-7

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10.1016/S0165-2427(96)05612-7