Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils

K. M. Lam; M. B. Kabbur; J. P. Eiserich

doi:10.1016/S0165-2427(96)05612-7

Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils

K. M. Lam, M. B. Kabbur, J. P. Eiserich

Nephrology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H₂O₂ production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.

Original language	English (US)
Pages (from-to)	313-327
Number of pages	15
Journal	Veterinary Immunology and Immunopathology
Volume	53
Issue number	3-4
DOIs	https://doi.org/10.1016/S0165-2427(96)05612-7
State	Published - Oct 1996

Keywords

Chicken
Heterophils
Newcastle disease virus

ASJC Scopus subject areas

Animal Science and Zoology
Immunology
veterinary(all)

Access to Document

10.1016/S0165-2427(96)05612-7

Fingerprint Dive into the research topics of 'Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils'. Together they form a unique fingerprint.

Cite this

@article{d859e26d3b964b48953fd241a5598cb4,

title = "Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils",

abstract = "The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.",

keywords = "Chicken, Heterophils, Newcastle disease virus",

author = "Lam, {K. M.} and Kabbur, {M. B.} and Eiserich, {J. P.}",

year = "1996",

month = oct,

doi = "10.1016/S0165-2427(96)05612-7",

language = "English (US)",

volume = "53",

pages = "313--327",

journal = "Veterinary Immunology and Immunopathology",

issn = "0165-2427",

publisher = "Elsevier",

number = "3-4",

}

TY - JOUR

T1 - Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils

AU - Lam, K. M.

AU - Kabbur, M. B.

AU - Eiserich, J. P.

PY - 1996/10

Y1 - 1996/10

N2 - The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.

AB - The GB strain of Newcastle disease virus (NDV) is used to infect chicken heterophils in vitro. Heterophils have a decreased ability to phagocytize bacteria 3 h after infection, and those that did engulfed fewer bacteria relative to non-infected heterophils. Infected heterophils have a decreased H2O2 production as shown by flow cytometry, but an increased nitric oxide production, suggesting that NDV can stimulate heterophils to produce and/or utilize nitrogen intermediates but not oxygen intermediates. DNA extracted from the infected heterophils shows a marked fragmentation, suggesting that NDV infection may cause heterophils to undergo apoptosis.

KW - Chicken

KW - Heterophils

KW - Newcastle disease virus

UR - http://www.scopus.com/inward/record.url?scp=0030272579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030272579&partnerID=8YFLogxK

U2 - 10.1016/S0165-2427(96)05612-7

DO - 10.1016/S0165-2427(96)05612-7

M3 - Article

C2 - 8969051

AN - SCOPUS:0030272579

VL - 53

SP - 313

EP - 327

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

SN - 0165-2427

IS - 3-4

ER -

Newcastle disease virus-induced functional impairments and biochemical changes in chicken heterophils

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this