New synthetic method for benzofurans from 2-(cyanomethyl)phenyl derivatives

Hee Jun Kim, Jai Seo, Min Hyung Lee, Dong Seok Shin, Hyeong Baik Kim, Hyeongjin Cho, Byoung Se Lee, Dae Yoon Chi

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A convenient and mild synthetic method of synthesizing benzofuran from various 2-(cyanomethyl)phenyl carbonyl compounds under reduced oxygen conditions is reported. Nine C-2 substituted benzofurans were synthesized at 52-89%.

Original languageEnglish (US)
Pages (from-to)3942-3947
Number of pages6
JournalTetrahedron
Volume68
Issue number21
DOIs
StatePublished - May 27 2012
Externally publishedYes

Keywords

  • Benzofuran
  • Benzyl cyanide
  • C2-substituted benzofuran
  • C3-carboxylated benzofuran
  • Intramolecular cyclization

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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