New quantitative approach to analyze capillary permeability data that combines junctional pores and a fiber layer at the cleft entrance

Ruey Yug Tsay, Fitz Roy E Curry, Sheldon Weinbaum

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A three dimensional junction-pore-matrix model is applied to examine the role of the intercellular junction and matrix structures in the regulation of capillary permeability. In this studies a new hydrodynamic theory has been developed to examine the effect of a thin fiber layer at the entrance of the cleft. The fiber matrix structure is represented by either a perpendicular array of cylindrical posts or a porous medium with parallel channels running perpendicular to the lumen front at the entrance of the cleft. Our results indicate that a cleft with large junctional gaps of 22×44 nm and gap spacing of 480 nm and a fiber matrix with open spacing Δ ≈ 7nm can fit the measured values for solute permeability for small ions and large molecules of the size close to albumin and the values for hydraulic conductivities with and without a surface fiber layer present. However, it can not also fit the measured values of solute permeability for the intermediate size solutes. Therefore, it is clear that by considering the hydrodynamic forces alone, a cleft with uniform size junctional pores and a fiber matrix layer does not offer enough diffusive resistance for the intermediate size solutes.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
Place of PublicationNew York, NY, United States
PublisherPubl by ASME
Pages43-49
Number of pages7
Volume189
ISBN (Print)0791808785
StatePublished - 1991
Externally publishedYes
EventWinter Annual Meeting of the American Society of Mechanical Engineers - Atlanta, GA, USA
Duration: Dec 1 1991Dec 6 1991

Other

OtherWinter Annual Meeting of the American Society of Mechanical Engineers
CityAtlanta, GA, USA
Period12/1/9112/6/91

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes
  • Mechanical Engineering

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  • Cite this

    Tsay, R. Y., Curry, F. R. E., & Weinbaum, S. (1991). New quantitative approach to analyze capillary permeability data that combines junctional pores and a fiber layer at the cleft entrance. In American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD (Vol. 189, pp. 43-49). Publ by ASME.