New prospects and strategies for drug target discovery in neurodegenerative disorders

Brian S. Hilbush, John Morrison, Warren G. Young, J. Gregor Sutcliffe, Floyd E. Bloom

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

The future of neurodegenerative therapeutics development depends upon effective disease modification strategies centered on carefully investigated targets. Pharmaceutical research endeavors that probe for a much deeper understanding of disease pathogenesis, and explain how adaptive or compensatory mechanisms might be engaged to delay disease onset or progression, will produce the needed breakthroughs. Below, we discuss the prospects for new targets emerging out of the study of brain disease genes and their associated pathogenic pathways. We describe a general experimental paradigm that we are employing across several mouse models of neurodegenerative disease to elucidate molecular determinants of selective neuronal vulnerability. We outline key elements of our target discovery program and provide examples of how we integrate genomic technologies, neuroanatomical methods, and mouse genetics in the search for neurodegenerative disease targets.

Original languageEnglish (US)
Pages (from-to)627-637
Number of pages11
JournalNeuroRx
Volume2
Issue number4
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Keywords

  • Alzheimer's
  • Genes
  • Genomics
  • Neurodegeneration
  • QTL
  • Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

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