New Onset Psychosis Following Abrupt Discontinuation of Hormone Replacement Therapy in a Trans Woman

Scott M. Summers, John C Onate

Research output: Contribution to journalArticle

5 Scopus citations


Estrogen and related hormones have a significant role to play in the etiology and the treatment of psychotic illness. Here we present the case of a 38-year-old immigrant trans woman referred for management of first onset psychotic symptoms following abrupt discontinuation of female hormonal therapy first started in adolescence. The patient's symptoms progressed to catatonia, but were eventually treated with significant success by a combination of clozapine, estradiol and medroxyprogesterone.

Original languageEnglish (US)
Pages (from-to)312-319
Number of pages8
JournalJournal of Gay and Lesbian Mental Health
Issue number3
StatePublished - 2014



  • estrogen
  • neuroendocrinology
  • psychosis
  • schizophrenia
  • transgender

ASJC Scopus subject areas

  • Clinical Psychology
  • Health(social science)
  • Psychiatry and Mental health

Cite this