Abstract
Renal involvement is the major factor determining the long-term outcome of children with Henoch-Schönlein Purpura (SP) nephritis. The precise incidence of adverse outcomes is debatable; moreover, there are conflicting data on the validity of prognostic factors for predicting adverse outcome in children with HSP nephritis. Difficulties in prognostication are compounded by lack of non-invasive diagnostic methods in children suspected of having HSP. The purpose of this article is to review recent data evaluating the role of serum galactose-deficient IgA in the pathogenesis of HSP nephritis and its potential role as a non-invasive diagnostic tool. Recent studies evaluating the role of prognostic markers and the risk of adverse long-term outcomes in children with HSP nephritis are also described. HSP nephritis, although relatively benign in most children, can lead to significant chronic kidney disease in a subset of children, especially on very long-term follow-up. Health-care providers need to be aware of this and tailor appropriate follow-up and screening tests to identify early signs of renal functional deterioration, so that therapies that can retard the rate of progression can be instituted early.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 58-65 |
| Number of pages | 8 |
| Journal | Current Pediatric Reviews |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2008 |
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Keywords
- Aberrantly glycosylated IgA1
- Children
- Henoch-Schönlein Purpura nephritis
- Pathogenesis
- Prognosis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
New insights into the pathogenesis of and long-term risks in children with Henoch-Schönlein Purpura nephritis. / Lau, Keith K.; Butani, Lavjay.
In: Current Pediatric Reviews, Vol. 4, No. 1, 02.2008, p. 58-65.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New insights into the pathogenesis of and long-term risks in children with Henoch-Schönlein Purpura nephritis
AU - Lau, Keith K.
AU - Butani, Lavjay
PY - 2008/2
Y1 - 2008/2
N2 - Renal involvement is the major factor determining the long-term outcome of children with Henoch-Schönlein Purpura (SP) nephritis. The precise incidence of adverse outcomes is debatable; moreover, there are conflicting data on the validity of prognostic factors for predicting adverse outcome in children with HSP nephritis. Difficulties in prognostication are compounded by lack of non-invasive diagnostic methods in children suspected of having HSP. The purpose of this article is to review recent data evaluating the role of serum galactose-deficient IgA in the pathogenesis of HSP nephritis and its potential role as a non-invasive diagnostic tool. Recent studies evaluating the role of prognostic markers and the risk of adverse long-term outcomes in children with HSP nephritis are also described. HSP nephritis, although relatively benign in most children, can lead to significant chronic kidney disease in a subset of children, especially on very long-term follow-up. Health-care providers need to be aware of this and tailor appropriate follow-up and screening tests to identify early signs of renal functional deterioration, so that therapies that can retard the rate of progression can be instituted early.
AB - Renal involvement is the major factor determining the long-term outcome of children with Henoch-Schönlein Purpura (SP) nephritis. The precise incidence of adverse outcomes is debatable; moreover, there are conflicting data on the validity of prognostic factors for predicting adverse outcome in children with HSP nephritis. Difficulties in prognostication are compounded by lack of non-invasive diagnostic methods in children suspected of having HSP. The purpose of this article is to review recent data evaluating the role of serum galactose-deficient IgA in the pathogenesis of HSP nephritis and its potential role as a non-invasive diagnostic tool. Recent studies evaluating the role of prognostic markers and the risk of adverse long-term outcomes in children with HSP nephritis are also described. HSP nephritis, although relatively benign in most children, can lead to significant chronic kidney disease in a subset of children, especially on very long-term follow-up. Health-care providers need to be aware of this and tailor appropriate follow-up and screening tests to identify early signs of renal functional deterioration, so that therapies that can retard the rate of progression can be instituted early.
KW - Aberrantly glycosylated IgA1
KW - Children
KW - Henoch-Schönlein Purpura nephritis
KW - Pathogenesis
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=41949125464&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41949125464&partnerID=8YFLogxK
U2 - 10.2174/157339608783565789
DO - 10.2174/157339608783565789
M3 - Article
AN - SCOPUS:41949125464
VL - 4
SP - 58
EP - 65
JO - Current Pediatric Reviews
JF - Current Pediatric Reviews
SN - 1573-3963
IS - 1
ER -