New insights into the pathogenesis of and long-term risks in children with Henoch-Schönlein Purpura nephritis

Keith K. Lau, Lavjay Butani

Research output: Contribution to journalArticlepeer-review


Renal involvement is the major factor determining the long-term outcome of children with Henoch-Schönlein Purpura (SP) nephritis. The precise incidence of adverse outcomes is debatable; moreover, there are conflicting data on the validity of prognostic factors for predicting adverse outcome in children with HSP nephritis. Difficulties in prognostication are compounded by lack of non-invasive diagnostic methods in children suspected of having HSP. The purpose of this article is to review recent data evaluating the role of serum galactose-deficient IgA in the pathogenesis of HSP nephritis and its potential role as a non-invasive diagnostic tool. Recent studies evaluating the role of prognostic markers and the risk of adverse long-term outcomes in children with HSP nephritis are also described. HSP nephritis, although relatively benign in most children, can lead to significant chronic kidney disease in a subset of children, especially on very long-term follow-up. Health-care providers need to be aware of this and tailor appropriate follow-up and screening tests to identify early signs of renal functional deterioration, so that therapies that can retard the rate of progression can be instituted early.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalCurrent Pediatric Reviews
Issue number1
StatePublished - Feb 2008


  • Aberrantly glycosylated IgA1
  • Children
  • Henoch-Schönlein Purpura nephritis
  • Pathogenesis
  • Prognosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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