New insights into lipid metabolism in chronic kidney disease

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Disorders in lipid levels in kidney disease consist of alterations both in the levels of the differing lipoprotein classes as well as alteration in their structures. Triglycerides (TGs) are increased, and both high density lipoprotein (HDL) and low density lipoprotein (LDL) levels are reduced. HDL fails to mature normally primarily as a consequence of decreased activity of lecithin cholesterol ester transfer protein (LCAT), and HDL levels are reduced because of increase clearance. The HDL that is present consist of small pre-β discoid HDL that fails to function as an antioxidant. All of the apo B containing lipoproteins exhibit decreased clearance in part because of increased levels of the lipoprotein lipase inhibitory apolipoproteins apo C I and apo C III. The concentration of oxidized LD, an athorgenic risk factor, is increased, in part because of the inability of the HDL that is present to reduce oxidized LDL and in part because of the increased LDL residence time effected by decreased clearance.

Original languageEnglish (US)
Pages (from-to)120-123
Number of pages4
JournalJournal of Renal Nutrition
Volume21
Issue number1
DOIs
StatePublished - Jan 2011

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HDL Lipoproteins
Chronic Renal Insufficiency
Lipid Metabolism
Apolipoprotein C-I
LDL Lipoproteins
Lipoproteins
Apolipoprotein C-III
Cholesterol Ester Transfer Proteins
Lecithins
Lipoprotein Lipase
Kidney Diseases
Apolipoproteins B
Triglycerides
Antioxidants
Lipids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Nephrology

Cite this

New insights into lipid metabolism in chronic kidney disease. / Kaysen, George.

In: Journal of Renal Nutrition, Vol. 21, No. 1, 01.2011, p. 120-123.

Research output: Contribution to journalArticle

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